UniProt Accession

 MTAP_YEAST; Q07938; D6VY19; E9P915; Q06899 

Genbank Protein ID

 X90564; Z73189; AY693070; BK006945 

Genbank Nucleotide ID

 CAA62156.1; CAA97539.1; AAT93089.1; DAA09335.1 

Protein Name

 S-methyl-5'-thioadenosine phosphorylase 

Protein Synonyms/Alias

 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase; Multicopy enhancer of UAS2 

Gene Name

 MEU1 

Gene Synonyms/Alias

 YLR017W; L1595 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
237	MSVIPEAKLARECEL	ubiquitination	[1]
317	IKKSISTKPEAMSKE	acetylation	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates. Seems to be implicated in the regulation of the expression of the ADH2 gene. 

Sequence Annotation

 REGION 88 89 Phosphate binding (By similarity).
 REGION 121 122 Phosphate binding (By similarity).
 REGION 254 256 Substrate binding (By similarity).
 BINDING 41 41 Phosphate (By similarity).
 BINDING 230 230 Substrate; via amide nitrogen (By
 BINDING 231 231 Phosphate (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Glycosyltransferase; Nucleus; Purine salvage; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 337 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003729; F:mRNA binding; IDA:SGD.
 GO:0004645; F:phosphorylase activity; IEA:InterPro.
 GO:0017061; F:S-methyl-5-thioadenosine phosphorylase activity; IDA:SGD.
 GO:0006537; P:glutamate biosynthetic process; IMP:SGD.
 GO:0019509; P:L-methionine salvage from methylthioadenosine; IDA:SGD.
 GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW. 

Interpro

 IPR010044; MTAP.
 IPR000845; Nucleoside_phosphorylase_d.
 IPR001369; PNP/MTAP.
 IPR018099; Purine_phosphorylase-2_CS. 

Pfam

 PF01048; PNP_UDP_1 

SMART

  

PROSITE

 PS01240; PNP_MTAP_2 

PRINTS