CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020818
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma 
Protein Synonyms/Alias
 1-acylglycerol-3-phosphate O-acyltransferase 3; 1-AGP acyltransferase 3; 1-AGPAT 3; Lysophosphatidic acid acyltransferase gamma; LPAAT-gamma 
Gene Name
 Agpat3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
195SMEVAASKGLPPLKYubiquitination[1]
201SKGLPPLKYHLLPRTubiquitination[1]
236TLNFRGNKNPSLLGIubiquitination[1]
247LLGILYGKKYEADMCubiquitination[1]
281LHKLYQEKDALQEMYubiquitination[1]
291LQEMYKQKGVFPGEQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA. 
Sequence Annotation
 MOTIF 96 101 HXXXXD motif.  
Keyword
 Acyltransferase; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Lipid biosynthesis; Lipid metabolism; Membrane; Nucleus; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 376 AA 
Protein Sequence
MGLLAYLKTQ FVVHLLIGFV FVVSGLIINF TQLCTLALWP ISKHLYRRIN CRLAYSLWSQ 60
LVMLLEWWSC TECTLFTDQA TVDHFGKEHV VVILNHNFEI DFLCGWTMCE RFGVLGSSKV 120
LAKRELLCVP LIGWTWYFLE IVFCKRKWEE DRDTVIEGLR RLADYPEYMW FLLYCEGTRF 180
TETKHRISME VAASKGLPPL KYHLLPRTKG FTTAVQCLRG TVAAIYDVTL NFRGNKNPSL 240
LGILYGKKYE ADMCVRRFPL EDIPADETSA AQWLHKLYQE KDALQEMYKQ KGVFPGEQFK 300
PARRPWTLLN FLCWATILLS PLFSFVLGVF ASGSPLLILT FLGFVGAASF GVRRLIGVTE 360
IEKGSSYGNQ ELKKKE 376 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0003841; F:1-acylglycerol-3-phosphate O-acyltransferase activity; IEA:EC.
 GO:0016024; P:CDP-diacylglycerol biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR002123; Plipid/glycerol_acylTrfase. 
Pfam
 PF01553; Acyltransferase 
SMART
 SM00563; PlsC 
PROSITE
  
PRINTS