| Tag | Content |
|---|
| CPLM ID | CPLM-022453 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Intersectin-2 |
Protein Synonyms/Alias | SH3 domain-containing protein 1B; SH3P18; SH3P18-like WASP-associated protein |
Gene Name | ITSN2 |
Gene Synonyms/Alias | KIAA1256; SH3D1B; SWAP |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 583 | SGVSLLHKKSLEKEE | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). |
Sequence Annotation | DOMAIN 22 110 EH 1.
DOMAIN 54 89 EF-hand.
DOMAIN 244 333 EH 2.
DOMAIN 757 818 SH3 1.
DOMAIN 898 956 SH3 2.
DOMAIN 981 1039 SH3 3.
DOMAIN 1053 1117 SH3 4.
DOMAIN 1127 1186 SH3 5.
DOMAIN 1209 1395 DH.
DOMAIN 1434 1544 PH.
DOMAIN 1556 1652 C2.
MOD_RES 210 210 Phosphoserine.
MOD_RES 230 230 Phosphoserine.
MOD_RES 553 553 Phosphotyrosine (By similarity).
MOD_RES 573 573 Phosphothreonine.
MOD_RES 889 889 Phosphoserine.
MOD_RES 968 968 Phosphotyrosine. |
Keyword | 3D-structure; Alternative splicing; Calcium; Coiled coil; Complete proteome; Cytoplasm; Endocytosis; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1697 AA |
Protein Sequence | MMAQFPTAMN GGPNMWAITS EERTKHDRQF DNLKPSGGYI TGDQARNFFL QSGLPAPVLA 60
EIWALSDLNK DGKMDQQEFS IAMKLIKLKL QGQQLPVVLP PIMKQPPMFS PLISARFGMG 120
SMPNLSIPQP LPPAAPITSL SSATSGTNLP PLMMPTPLVP SVSTSSLPNG TASLIQPLPI 180
PYSSSTLPHG SSYSLMMGGF GGASIQKAQS LIDLGSSSST SSTASLSGNS PKTGTSEWAV 240
PQPTRLKYRQ KFNTLDKSMS GYLSGFQARN ALLQSNLSQT QLATIWTLAD VDGDGQLKAE 300
EFILAMHLTD MAKAGQPLPL TLPPELVPPS FRGGKQIDSI NGTLPSYQKM QEEEPQKKLP 360
VTFEDKRKAN YERGNMELEK RRQALMEQQQ REAERKAQKE KEEWERKQRE LQEQEWKKQL 420
ELEKRLEKQR ELERQREEER RKDIERREAA KQELERQRRL EWERIRRQEL LNQKNREQEE 480
IVRLNSKKKN LHLELEALNG KHQQISGRLQ DVRLKKQTQK TELEVLDKQC DLEIMEIKQL 540
QQELQEYQNK LIYLVPEKQL LNERIKNMQF SNTPDSGVSL LHKKSLEKEE LCQRLKEQLD 600
ALEKETASKL SEMDSFNNQL KELRETYNTQ QLALEQLYKI KRDKLKEIER KRLELMQKKK 660
LEDEAARKAK QGKENLWKEN LRKEEEEKQK RLQEEKTQEK IQEEERKAEE KQRKDKDTLK 720
AEEKKRETAS VLVNYRALYP FEARNHDEMS FNSGDIIQVD EKTVGEPGWL YGSFQGNFGW 780
FPCNYVEKMP SSENEKAVSP KKALLPPTVS LSATSTSSEP LSSNQPASVT DYQNVSFSNL 840
TVNTSWQKKS AFTRTVSPGS VSPIHGQGQV VENLKAQALC SWTAKKDNHL NFSKHDIITV 900
LEQQENWWFG EVHGGRGWFP KSYVKIIPGS EVKREEPEAL YAAVNKKPTS AAYSVGEEYI 960
ALYPYSSVEP GDLTFTEGEE ILVTQKDGEW WTGSIGDRSG IFPSNYVKPK DQESFGSASK 1020
SGASNKKPEI AQVTSAYVAS GSEQLSLAPG QLILILKKNT SGWWQGELQA RGKKRQKGWF 1080
PASHVKLLGP SSERATPAFH PVCQVIAMYD YAANNEDELS FSKGQLINVM NKDDPDWWQG 1140
EINGVTGLFP SNYVKMTTDS DPSQQWCADL QTLDTMQPIE RKRQGYIHEL IQTEERYMAD 1200
LQLVVEVFQK RMAESGFLTE GEMALIFVNW KELIMSNTKL LKALRVRKKT GGEKMPVQMI 1260
GDILAAELSH MQAYIRFCSC QLNGAALLQQ KTDEDTDFKE FLKKLASDPR CKGMPLSSFL 1320
LKPMQRITRY PLLIRSILEN TPESHADHSS LKLALERAEE LCSQVNEGVR EKENSDRLEW 1380
IQAHVQCEGL AEQLIFNSLT NCLGPRKLLH SGKLYKTKSN KELHGFLFND FLLLTYMVKQ 1440
FAVSSGSEKL FSSKSNAQFK MYKTPIFLNE VLVKLPTDPS SDEPVFHISH IDRVYTLRTD 1500
NINERTAWVQ KIKAASEQYI DTEKKKREKA YQARSQKTSG IGRLMVHVIE ATELKACKPN 1560
GKSNPYCEIS MGSQSYTTRT IQDTLNPKWN FNCQFFIKDL YQDVLCLTLF DRDQFSPDDF 1620
LGRTEIPVAK IRTEQESKGP MTRRLLLHEV PTGEVWVRFD LQLFEQKTLL 1670 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc. GO:0006897; P:endocytosis; IEA:UniProtKB-KW. GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |