CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014597
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ADP-ribosyl cyclase 1 
Protein Synonyms/Alias
 CD38H; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; CD38 
Gene Name
 Cd38 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
93KKILSTFKRGFISKNacetylation[1]
130NKTLFWSKSKHLAHQacetylation[1]
240LDPNKVHKLQAWVMHacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. 
Sequence Annotation
 ACT_SITE 122 122 By similarity.
 ACT_SITE 204 204 By similarity.
 CARBOHYD 103 103 N-linked (GlcNAc...) (Potential).
 CARBOHYD 123 123 N-linked (GlcNAc...) (Potential).
 CARBOHYD 212 212 N-linked (GlcNAc...) (Potential).
 CARBOHYD 222 222 N-linked (GlcNAc...) (Potential).
 DISULFID 69 85 By similarity.
 DISULFID 102 183 By similarity.
 DISULFID 163 176 By similarity.
 DISULFID 257 278 By similarity.
 DISULFID 290 299 By similarity.  
Keyword
 Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Membrane; NAD; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 303 AA 
Protein Sequence
MANYEFSQVS EDRPGCRLTR KAQIGLGVGL LLLVALVVVV VIVLWPRSPL VWKGKPTTKH 60
FADIILGRCL IYTQILRPEM RDQDCKKILS TFKRGFISKN PCNITNEDYA PLVKLVTQTI 120
PCNKTLFWSK SKHLAHQYTW IQGKMFTLED TLLGYIADDL RWCGDPSTSD MNYDSCPHWS 180
ENCPNNPVAV FWNVISQKFA EDACGVVQVM LNGSLSEPFY RNSTFGSVEV FNLDPNKVHK 240
LQAWVMHDIK GTSSNACSSP SINELKSIVN KRNMIFACQD NYRPVRFLQC VKNPEHPSCR 300
LNV 303 
Gene Ontology
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0003953; F:NAD+ nucleosidase activity; IDA:RGD.
 GO:0016849; F:phosphorus-oxygen lyase activity; IEA:Compara.
 GO:0050853; P:B cell receptor signaling pathway; IEA:Compara.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IMP:RGD.
 GO:0007565; P:female pregnancy; IEP:RGD.
 GO:0060292; P:long term synaptic depression; IMP:RGD.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0045779; P:negative regulation of bone resorption; IDA:RGD.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0030890; P:positive regulation of B cell proliferation; IEA:Compara.
 GO:0030307; P:positive regulation of cell growth; IMP:RGD.
 GO:0032024; P:positive regulation of insulin secretion; IMP:RGD.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0045907; P:positive regulation of vasoconstriction; IMP:RGD.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0033194; P:response to hydroperoxide; IDA:RGD.
 GO:0001666; P:response to hypoxia; IDA:RGD.
 GO:0070555; P:response to interleukin-1; IEP:RGD.
 GO:0032570; P:response to progesterone stimulus; IEP:RGD.
 GO:0032526; P:response to retinoic acid; IEP:RGD. 
Interpro
 IPR003193; ADP-ribosyl_cyclase.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF02267; Rib_hydrolayse 
SMART
  
PROSITE
  
PRINTS