CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000738
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein sprouty homolog 1 
Protein Synonyms/Alias
 Spry-1 
Gene Name
 SPRY1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
306NSNTVYCKLESCPSRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. 
Sequence Annotation
 DOMAIN 183 295 SPR.  
Keyword
 Complete proteome; Cytoplasm; Developmental protein; Membrane; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 319 AA 
Protein Sequence
MDPQNQHGSG SSLVVIQQPS LDSRQRLDYE REIQPTAILS LDQIKAIRGS NEYTEGPSVV 60
KRPAPRTAPR QEKHERTHEI IPINVNNNYE HRHTSHLGHA VLPSNARGPI LSRSTSTGSA 120
ASSGSNSSAS SEQGLLGRSP PTRPVPGHRS ERAIRTQPKQ LIVDDLKGSL KEDLTQHKFI 180
CEQCGKCKCG ECTAPRTLPS CLACNRQCLC SAESMVEYGT CMCLVKGIFY HCSNDDEGDS 240
YSDNPCSCSQ SHCCSRYLCM GAMSLFLPCL LCYPPAKGCL KLCRRCYDWI HRPGCRCKNS 300
NTVYCKLESC PSRGQGKPS 319 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0030027; C:lamellipodium; NAS:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0001656; P:metanephros development; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Compara.
 GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IEA:Compara.
 GO:0043407; P:negative regulation of MAP kinase activity; IEA:Compara.
 GO:0051387; P:negative regulation of neurotrophin TRK receptor signaling pathway; IEA:Compara.
 GO:0034261; P:negative regulation of Ras GTPase activity; IEA:Compara.
 GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:Compara.
 GO:0001759; P:organ induction; IEA:Compara.
 GO:0001657; P:ureteric bud development; IEA:Compara. 
Interpro
 IPR007875; Sprouty. 
Pfam
 PF05210; Sprouty 
SMART
  
PROSITE
 PS51227; SPR 
PRINTS