UniProt Accession

 C9JQT7_HUMAN; C9JQT7 

Genbank Protein ID

 AC007620; AC007823 

Genbank Nucleotide ID

  

Protein Name

 Mitofusin-1 

Protein Synonyms/Alias

  

Gene Name

 MFN1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
6	**MDKDLKAGCLVRV	ubiquitination	[1]
75	TEKHFFHKVNERLSK	ubiquitination	[2]
82	KVNERLSKPNIFILN	ubiquitination	[2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 124 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005741; C:mitochondrial outer membrane; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:InterPro.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:0008053; P:mitochondrial fusion; IEA:Compara. 

Interpro

 IPR001401; Dynamin_GTPase.
 IPR027088; Mitofusin-1.
 IPR027094; Mitofusin_fam.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00350; Dynamin_N 

SMART

  

PROSITE

  

PRINTS