UniProt Accession

 ATG12_MOUSE; Q9CQY1; Q3TKE5; Q9D7Y5 

Genbank Protein ID

 AB066216; AK008698; AK016474; AK005405; AK167027; BC070470 

Genbank Nucleotide ID

 BAB62092.1; BAB25839.1; BAB30256.1; BAB24005.1; BAE39200.1; AAH70470.1 

Protein Name

 Ubiquitin-like protein ATG12 

Protein Synonyms/Alias

 Autophagy-related protein 12; APG12-like 

Gene Name

 Atg12 

Gene Synonyms/Alias

 Apg12; Apg12l 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
90	QGLIDFIKKFLKLVA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through an ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus. 

Sequence Annotation

 CROSSLNK 141 141 Glycyl lysine isopeptide (Gly-Lys)  

Keyword

 Acetylation; Autophagy; Complete proteome; Cytoplasm; Immunity; Innate immunity; Isopeptide bond; Membrane; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 141 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0034045; C:pre-autophagosomal structure membrane; IDA:UniProtKB.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0000045; P:autophagic vacuole assembly; IMP:UniProtKB.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW. 

Interpro

 IPR007242; Atg12. 

Pfam

 PF04110; APG12 

SMART

  

PROSITE

  

PRINTS