CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017982
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable E3 ubiquitin-protein ligase RNF217 
Protein Synonyms/Alias
 IBR domain-containing protein 1; RING finger protein 217 
Gene Name
 RNF217 
Gene Synonyms/Alias
 C6orf172; IBRDC1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
183NLSIFGCKYRYLPERubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). 
Sequence Annotation
 ZN_FING 36 104 IBR-type.
 ZN_FING 131 160 RING-type.  
Keyword
 Complete proteome; Ligase; Membrane; Metal-binding; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Ubl conjugation pathway; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 275 AA 
Protein Sequence
MKVQLGQVEI KCPITECFEF LEETTVVYNL THEDSIKYKY FLELGRIDSS TKPCPQCKHF 60
TTFKKKGHIP TPSRSESKYK IQCPTCQFVW CFKCHSPWHE GVNCKEYKKG DKLLRHWASE 120
IEHGQRNAQK CPKCKIHIQR TEGCDHMTCS QCNTNFCYRC GERYRQLRFF GDHTSNLSIF 180
GCKYRYLPER PHLRRLVRGS VCAGKLFIAP LIMVLGLALG AIAVVIVEEI KTYWNLISGR 240
TRNQTQHLAP QPVLLSDMLY CLKQVFICIS YLLPL 275 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB. 
Interpro
 IPR002867; Znf_C6HC. 
Pfam
 PF01485; IBR 
SMART
 SM00647; IBR 
PROSITE
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS