UniProt Accession

 SPHK1_HUMAN; Q9NYA1; Q8N632; Q96GK1; Q9HD92; Q9NY70; Q9NYL3 

Genbank Protein ID

 AF266756; AF238083; AF200328; AK023393; AK292294; AK022402; AJ245504; AC090699; CH471099; CH471099; BC009419; BC014439; BC030553 

Genbank Nucleotide ID

 AAF73470.1; AAF73423.1; AAG01980.1; BAB14558.1; BAF84983.1; BAB14028.1; CAB92131.1; EAW89392.1; EAW89393.1; AAH09419.1; AAH14439.1; AAH30553.1 

Protein Name

 Sphingosine kinase 1 

Protein Synonyms/Alias

 SK 1; SPK 1 

Gene Name

 SPHK1 

Gene Synonyms/Alias

 SPHK; SPK 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
58	ARLGSTDKELKAGAA	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. 

Sequence Annotation

 DOMAIN 12 159 DAGKc.
 MOTIF 147 155 Nuclear export signal 1.
 MOTIF 161 169 Nuclear export signal 2.
 MOD_RES 193 193 Phosphothreonine.
 MOD_RES 225 225 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; ATP-binding; Calmodulin-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 384 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:BHF-UCL.
 GO:0005524; F:ATP binding; IDA:UniProtKB.
 GO:0005516; F:calmodulin binding; IDA:UniProtKB.
 GO:0017050; F:D-erythro-sphingosine kinase activity; IDA:UniProtKB.
 GO:0004143; F:diacylglycerol kinase activity; IEA:InterPro.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
 GO:0008481; F:sphinganine kinase activity; IDA:MGI.
 GO:0051084; P:'de novo' posttranslational protein folding; TAS:Reactome.
 GO:0001568; P:blood vessel development; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0019722; P:calcium-mediated signaling; IDA:UniProtKB.
 GO:0006954; P:inflammatory response; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB.
 GO:0045766; P:positive regulation of angiogenesis; IDA:UniProtKB.
 GO:0030307; P:positive regulation of cell growth; IDA:UniProtKB.
 GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.
 GO:0048146; P:positive regulation of fibroblast proliferation; IDA:MGI.
 GO:0045931; P:positive regulation of mitotic cell cycle; IDA:UniProtKB.
 GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IMP:UniProtKB.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.
 GO:0031398; P:positive regulation of protein ubiquitination; IDA:UniProtKB.
 GO:0045987; P:positive regulation of smooth muscle contraction; IDA:UniProtKB.
 GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; IEA:InterPro.
 GO:0032651; P:regulation of interleukin-1 beta production; IEA:Compara.
 GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway; IDA:UniProtKB.
 GO:0046521; P:sphingoid catabolic process; NAS:UniProtKB.
 GO:0030148; P:sphingolipid biosynthetic process; TAS:Reactome.
 GO:0006670; P:sphingosine metabolic process; IDA:UniProtKB. 

Interpro

 IPR001206; Diacylglycerol_kinase_cat_dom. 

Pfam

 PF00781; DAGK_cat 

SMART

 SM00046; DAGKc 

PROSITE

 PS50146; DAGK 

PRINTS