| Tag | Content |
|---|
| CPLM ID | CPLM-023305 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sialidase-3 |
Protein Synonyms/Alias | Ganglioside sialidase; Membrane sialidase; N-acetyl-alpha-neuraminidase 3 |
Gene Name | NEU3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 426 | GRNPSQFKSN***** | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates. |
Sequence Annotation | REPEAT 129 140 BNR 1.
REPEAT 203 214 BNR 2.
REPEAT 254 265 BNR 3.
MOTIF 24 27 FRIP motif.
ACT_SITE 50 50 Proton acceptor (By similarity).
ACT_SITE 370 370 Nucleophile (By similarity).
ACT_SITE 387 387 Potential.
BINDING 25 25 Substrate (By similarity).
BINDING 245 245 Substrate (Potential).
BINDING 340 340 Substrate (By similarity). |
Keyword | Complete proteome; Glycosidase; Hydrolase; Membrane; Polymorphism; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 428 AA |
Protein Sequence | MEEVTTCSFN SPLFRQEDDR GITYRIPALL YIPPTHTFLA FAEKRSTRRD EDALHLVLRR 60
GLRIGQLVQW GPLKPLMEAT LPGHRTMNPC PVWEQKSGCV FLFFICVRGH VTERQQIVSG 120
RNAARLCFIY SQDAGCSWSE VRDLTEEVIG SELKHWATFA VGPGHGIQLQ SGRLVIPAYT 180
YYIPSWFFCF QLPCKTRPHS LMIYSDDLGV TWHHGRLIRP MVTVECEVAE VTGRAGHPVL 240
YCSARTPNRC RAEALSTDHG EGFQRLALSR QLCEPPHGCQ GSVVSFRPLE IPHRCQDSSS 300
KDAPTIQQSS PGSSLRLEEE AGTPSESWLL YSHPTSRKQR VDLGIYLNQT PLEAACWSRP 360
WILHCGPCGY SDLAALEEEG LFGCLFECGT KQECEQIAFR LFTHREILSH LQGDCTSPGR 420
NPSQFKSN 428 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0016997; F:alpha-sialidase activity; IDA:MGI. GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:EC. GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:EC. GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:EC. GO:0005975; P:carbohydrate metabolic process; IDA:MGI. GO:0006689; P:ganglioside catabolic process; TAS:ProtInc. GO:0044281; P:small molecule metabolic process; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |