UniProt Accession

 MAP2_MOUSE; O08663 

Genbank Protein ID

 AB003144; AK076804; BC002213 

Genbank Nucleotide ID

 BAA19789.1; BAC36488.1; AAH02213.1 

Protein Name

 Methionine aminopeptidase 2 

Protein Synonyms/Alias

 MAP 2; MetAP 2; Initiation factor 2-associated 67 kDa glycoprotein; p67; p67eIF2; Peptidase M 

Gene Name

 Metap2 

Gene Synonyms/Alias

 Mnpep; P67eif2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
427	LDRLGESKYLMALKN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) (By similarity). 

Sequence Annotation

 METAL 251 251 Divalent metal cation 1 (By similarity).
 METAL 262 262 Divalent metal cation 1 (By similarity).
 METAL 262 262 Divalent metal cation 2; catalytic (By
 METAL 331 331 Divalent metal cation 2; catalytic; via
 METAL 364 364 Divalent metal cation 2; catalytic (By
 METAL 459 459 Divalent metal cation 1 (By similarity).
 METAL 459 459 Divalent metal cation 2; catalytic (By
 BINDING 231 231 Substrate (By similarity).
 BINDING 339 339 Substrate (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 60 60 Phosphoserine; alternate (By similarity).
 CARBOHYD 60 60 O-linked (GlcNAc); alternate (By  

Keyword

 Acetylation; Aminopeptidase; Complete proteome; Cytoplasm; Direct protein sequencing; Glycoprotein; Hydrolase; Metal-binding; Phosphoprotein; Protease; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 478 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:HGNC.
 GO:0004177; F:aminopeptidase activity; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008235; F:metalloexopeptidase activity; ISS:UniProtKB.
 GO:0031365; P:N-terminal protein amino acid modification; ISS:HGNC.
 GO:0018206; P:peptidyl-methionine modification; ISS:HGNC.
 GO:0016485; P:protein processing; ISS:HGNC.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR001714; Pept_M24_MAP.
 IPR000994; Pept_M24_structural-domain.
 IPR002468; Pept_M24A_MAP2.
 IPR018349; Pept_M24A_MAP2_BS.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00557; Peptidase_M24 

SMART

  

PROSITE

 PS01202; MAP_2 

PRINTS

 PR00599; MAPEPTIDASE.