CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025623
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dead end homolog 1 (Zebrafish) 
Protein Synonyms/Alias
 Histidyl-tRNA synthetase; Protein Hars 
Gene Name
 Hars 
Gene Synonyms/Alias
 Dnd1; rCG_49447 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
57GKQKFVLKTPKGTRDacetylation[1]
112GKYGEDSKLIYDLKDacetylation[1]
143ARYLAMNKLTNIKRYacetylation[1]
193IPDAECLKIMCEILSubiquitination[2]
293DPKLSQNKQAVEGLGubiquitination[2]
418VLVASAQKKLLEERLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminoacyl-tRNA synthetase; Complete proteome; Ligase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 508 AA 
Protein Sequence
MADRAALEEL VRLQGAHVRG LKEQKASAEQ IEEEVTKLLK LKAQLGHDEG KQKFVLKTPK 60
GTRDYSPRQM AVREKVFDVI IRCFKRHGAE VIDTPVFELK ETLTGKYGED SKLIYDLKDQ 120
GGELLSLRYD LTVPFARYLA MNKLTNIKRY HIAKVYRRDN PAMTRGRYRE FYQCDFDIAG 180
QFDPMIPDAE CLKIMCEILS SLQIGNFQVK VNDRRILDGM FAVCGVPDSK FRTICSSVDK 240
LDKVSWEEVK NEMVGEKGLA PEVADRIGDY VQQHGGVSLV EQLLQDPKLS QNKQAVEGLG 300
DLKLLFEYLT LFGIDDKISF DLSLARGLDY YTGVIYEAVL LQMPTQAGEE PLGVGSIAAG 360
GRYDGLVGMF DPKGRKVPCV GLSIGVERIF SIVEQKLEAS EEKVRTTETQ VLVASAQKKL 420
LEERLKLISE LWDAGIKAEL LYKKNPKLLN QLQYCEEAGI PLVAIIGEQE LKDGVIKLRS 480
VTSREEVDVR REDLVEEIRR RTSQPLSM 508 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004821; F:histidine-tRNA ligase activity; IEA:InterPro.
 GO:0006427; P:histidyl-tRNA aminoacylation; IEA:InterPro. 
Interpro
 IPR006195; aa-tRNA-synth_II.
 IPR004154; Anticodon-bd.
 IPR015807; His-tRNA-ligase.
 IPR004516; HisRS/HisZ.
 IPR009068; S15_NS1_RNA-bd.
 IPR000738; WHEP-TRS. 
Pfam
 PF03129; HGTP_anticodon
 PF00458; WHEP-TRS 
SMART
 SM00991; WHEP-TRS 
PROSITE
 PS50862; AA_TRNA_LIGASE_II
 PS00762; WHEP_TRS_1
 PS51185; WHEP_TRS_2 
PRINTS