UniProt Accession

 Q70WG0_HUMAN; Q70WG0 

Genbank Protein ID

 AC125238; AJ517504; CH471063 

Genbank Nucleotide ID

 CAD57003.1; EAW70348.1 

Protein Name

 CD28 antigen (Tp44), isoform CRA_b 

Protein Synonyms/Alias

 T-cell-specific surface glycoprotein; T-cell-specific surface glycoprotein CD28 

Gene Name

 CD28 

Gene Synonyms/Alias

 hCG_16886 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
152	TIIHVKGKHLCPSPL	ubiquitination	[1]
218	RRPGPTRKHYQPYAP	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 234 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:InterPro.
 GO:0006955; P:immune response; IEA:InterPro.
 GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; ISS:UniProtKB.
 GO:0045840; P:positive regulation of mitosis; ISS:UniProtKB.
 GO:0042102; P:positive regulation of T cell proliferation; ISS:UniProtKB. 

Interpro

 IPR008093; CD28.
 IPR013783; Ig-like_fold.
 IPR013106; Ig_V-set. 

Pfam

 PF07686; V-set 

SMART

  

PROSITE

  

PRINTS

 PR01717; CD28ANTIGEN.