Tag | Content |
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CPLM ID | CPLM-019678 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Alpha-2-macroglobulin receptor-associated protein |
Protein Synonyms/Alias | Alpha-2-MRAP; Gp330-binding 45 kDa protein; Low density lipoprotein receptor-related protein-associated protein 1; RAP |
Gene Name | Lrpap1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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68 | KLNQLWEKAKRLHLS | acetylation | [1] | 97 | ERDELNWKKLKVEGL | acetylation | [1] | 100 | ELNWKKLKVEGLDGD | acetylation | [1] | 110 | GLDGDGEKEAKLVHN | acetylation | [1] | 156 | LGDPRLEKLWHKAKT | acetylation | [1] | 166 | HKAKTSGKFSSEELD | acetylation | [1] | 183 | WREFLHYKEKIHEYN | acetylation | [1] | 185 | EFLHYKEKIHEYNVL | acetylation | [1] | 228 | ASKHSELKDRLRSIN | acetylation | [1] | 285 | ESFREELKHFEAKIE | acetylation | [1] | 290 | ELKHFEAKIEKHNHY | acetylation | [1] | 299 | EKHNHYQKQLEISHQ | acetylation | [1] | 307 | QLEISHQKLKHVESI | acetylation | [1] | 309 | EISHQKLKHVESIGD | acetylation | [1] | 326 | HISRNKEKYVLLEEK | acetylation | [1] | 333 | KYVLLEEKTKELGYK | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. |
Sequence Annotation | REGION 240 356 LDL receptor binding (Potential). MOTIF 357 360 Prevents secretion from ER (Potential). CARBOHYD 271 271 N-linked (GlcNAc...) (Potential). |
Keyword | Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Heparin-binding; Reference proteome; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 360 AA |
Protein Sequence | MAPLRDRVST LPRLQLLVLL LLPLLLVPQP IAGHGGKYSR EKNEPEMAAK RESGEEFRME 60 KLNQLWEKAK RLHLSPVRLA ELHSDLKIQE RDELNWKKLK VEGLDGDGEK EAKLVHNLNV 120 ILARYGLDGR KDTQTVHSNA LNEDTQDELG DPRLEKLWHK AKTSGKFSSE ELDKLWREFL 180 HYKEKIHEYN VLLDTLSRAE EGYENLLSPS DMTHIKSDTL ASKHSELKDR LRSINQGLDR 240 LRKVSHQGYG PATEFEEPRV IDLWDLAQSA NFTEKELESF REELKHFEAK IEKHNHYQKQ 300 LEISHQKLKH VESIGDPEHI SRNKEKYVLL EEKTKELGYK VKKHLQDLSS RVSRARHNEL 360 |
Gene Ontology | GO:0009986; C:cell surface; IEA:UniProtKB-SubCell. GO:0005576; C:extracellular region; IEA:Compara. GO:0005886; C:plasma membrane; IEA:Compara. GO:0048237; C:rough endoplasmic reticulum lumen; IDA:RGD. GO:0031982; C:vesicle; IDA:RGD. GO:0008201; F:heparin binding; IEA:UniProtKB-KW. GO:1900116; P:extracellular negative regulation of signal transduction; IEA:Compara. GO:1900222; P:negative regulation of beta-amyloid clearance; IEA:Compara. GO:0032091; P:negative regulation of protein binding; IEA:Compara. GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IEA:Compara. |
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PROSITE | |
PRINTS | |