CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032017
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanylate cyclase soluble subunit beta-1 
Protein Synonyms/Alias
 cDNA FLJ59711, highly similar to Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) 
Gene Name
 GUCY1B3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
145HGTEIDMKVIQQRNEubiquitination[1]
541ETTGEKGKINVSEYTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lyase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 599 AA 
Protein Sequence
MLMCFIKEAQ LDEEGQFLVR IIYDDSKTYD LVAAASKVLN LNAGEILQMF GKMFFVFCQE 60
SGYDTILRVL GSNVREFLQN LDALHDHLAT IYPGMRAPSF RCTDAEKGKG LILHYYSERE 120
GLQDIVIGII KTVAQQIHGT EIDMKVIQQR NEECDHTQFL IEEKESKEED FYEDLDRFEE 180
NGTQESRISP YTFCKAFPFH IIFDRDLVVT QCGNAIYRVL PQLQPGNCSL LSVFSLVRPH 240
IDISFHGILS HINTVFVLRS KEGLLDVEKL ECEDELTGTE ISCLRLKGQM IYLPEADSIL 300
FLCSPSVMNL DDLTRRGLYL SDIPLHDATR DLVLLGEQFR EEYKLTQELE ILTDRLQLTL 360
RALEDEKKKT DTLLYSVLPP SVANELRHKR PVPAKRYDNV TILFSGIVGF NAFCSKHASG 420
EGAMKIVNLL NDLYTRFDTL TDSRKNPFVY KVETVGDKYM TVSGLPEPCI HHARSICHLA 480
LDMMEIAGQV QVDGESVQIT IGIHTGEVVT GVIGQRMPRY CLFGNTVNLT SRTETTGEKG 540
KINVSEYTYR CLMSPENSDP QFHLEHRGPV SMKGKKEPMQ VWFLSRKNTG TEETKQDDD 599 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0004383; F:guanylate cyclase activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR001054; A/G_cyclase.
 IPR018297; A/G_cyclase_CS.
 IPR011645; Haem_no_assoc-bd.
 IPR011644; Heme_NO-bd.
 IPR024096; NO_sig/Golgi_transp_ligand-bd. 
Pfam
 PF00211; Guanylate_cyc
 PF07700; HNOB
 PF07701; HNOBA 
SMART
 SM00044; CYCc 
PROSITE
 PS00452; GUANYLATE_CYCLASE_1
 PS50125; GUANYLATE_CYCLASE_2 
PRINTS