CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022715
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein numb homolog 
Protein Synonyms/Alias
 m-Nb; m-Numb 
Gene Name
 Numb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
174ERKQKREKECGVTATubiquitination[1]
211AEREEIMKQLQDAKKubiquitination[1]
286GFPALSQKMSPFKRQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. 
Sequence Annotation
 DOMAIN 33 193 PID.
 MOD_RES 244 244 Phosphoserine (By similarity).
 MOD_RES 276 276 Phosphoserine; by CaMK1 (By similarity).
 MOD_RES 295 295 Phosphoserine; by CaMK1 (By similarity).
 MOD_RES 633 633 Phosphothreonine.
 MOD_RES 636 636 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Developmental protein; Membrane; Neurogenesis; Phosphoprotein; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 653 AA 
Protein Sequence
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED 60
AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD 120
RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA 180
TFDASRTTFT REGSFRVTTA TEQAEREEIM KQLQDAKKAE TDKTVVGPSV APGNTAPSPS 240
SPTSPTPDGT ASSEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE 300
LPSTMQRKTD FPIKNTVPEV EGEAESISSL CSQITSAFST PSEDPFSSAP MTKPVTLVAP 360
QSPVLQANGT DSASHVLTAK PANTALAHVA MPVRETNPWA HVPDAANKEI AAIHPGTEWG 420
QSSGAASPGL FQAGHRRTPS EADRWLEEVS KSVRAQQPQV SAAPLQPVLQ PPPPAAIAPP 480
APPFQGHAFL TSQPVPVGVV PPLQPAFVPT QSYPVANGMP YPASNVPVVG ITPSQMVANV 540
FGTAGHPQTT HPHQSPSLAK QQTFPQYETS SATTSPFFKP PAQHLNGSAA FNGVDNGGLA 600
SGNRHAEVPP GTCPVDPFEA QWAALESKSK QRTNPSPTNP FSSDLQKTFE IEL 653 
Gene Ontology
 GO:0045177; C:apical part of cell; IDA:MGI.
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0005769; C:early endosome; IDA:MGI.
 GO:0019897; C:extrinsic to plasma membrane; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0034332; P:adherens junction organization; IGI:MGI.
 GO:0007409; P:axonogenesis; IDA:MGI.
 GO:0021670; P:lateral ventricle development; IMP:UniProtKB.
 GO:0060487; P:lung epithelial cell differentiation; IMP:MGI.
 GO:0045746; P:negative regulation of Notch signaling pathway; IMP:MGI.
 GO:0021849; P:neuroblast division in subventricular zone; IMP:UniProtKB.
 GO:0050769; P:positive regulation of neurogenesis; IMP:UniProtKB.
 GO:0030862; P:positive regulation of polarized epithelial cell differentiation; IMP:MGI. 
Interpro
 IPR016698; Numb/numb-like.
 IPR010449; Numb_domain.
 IPR011993; PH_like_dom.
 IPR006020; PTyr_interaction_dom. 
Pfam
 PF06311; NumbF
 PF00640; PID 
SMART
 SM00462; PTB 
PROSITE
 PS01179; PID 
PRINTS