UniProt Accession

 BCAR1_MOUSE; Q61140; Q60869; Q6PFF9 

Genbank Protein ID

 U48853; U28151; AK145863; BC057578 

Genbank Nucleotide ID

 AAA93381.1; AAA93248.1; BAE26705.1; AAH57578.1 

Protein Name

 Breast cancer anti-estrogen resistance protein 1 

Protein Synonyms/Alias

 CRK-associated substrate; p130cas 

Gene Name

 Bcar1 

Gene Synonyms/Alias

 Cas; Crkas 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
697	GNIMRQGKGQLELQQ	ubiquitination	[1]
706	QLELQQLKQFERLEQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration (By similarity). Has been shown to be essential in cardiovascular development during embryogenesis. 

Sequence Annotation

 DOMAIN 6 26 SH3.
 REGION 119 420 Substrate for kinases (By similarity).
 REGION 750 800 Divergent helix-loop-helix motif.
 MOTIF 639 647 SH3-binding (Potential).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 132 132 Phosphotyrosine; by SRC (By similarity).
 MOD_RES 143 143 Phosphoserine (By similarity).
 MOD_RES 228 228 Phosphotyrosine.
 MOD_RES 238 238 Phosphotyrosine.
 MOD_RES 253 253 Phosphotyrosine; by ABL1.
 MOD_RES 273 273 Phosphothreonine (By similarity).
 MOD_RES 296 296 Phosphoserine (By similarity).
 MOD_RES 331 331 Phosphotyrosine.
 MOD_RES 366 366 Phosphotyrosine.
 MOD_RES 414 414 Phosphotyrosine.
 MOD_RES 432 432 Phosphoserine (By similarity).
 MOD_RES 441 441 Phosphoserine (By similarity).
 MOD_RES 643 643 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Cell adhesion; Cell junction; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; SH3 domain; SH3-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 874 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005925; C:focal adhesion; ISS:UniProtKB.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0001726; C:ruffle; ISS:UniProtKB.
 GO:0007015; P:actin filament organization; ISS:UniProtKB.
 GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0016477; P:cell migration; ISS:UniProtKB.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; ISS:UniProtKB.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:UniProtKB.
 GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
 GO:0007229; P:integrin-mediated signaling pathway; ISS:UniProtKB.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; ISS:UniProtKB.
 GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
 GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB. 

Interpro

 IPR021901; CAS_DUF3513.
 IPR014928; Serine_rich.
 IPR001452; SH3_domain.
 IPR013315; Spectrin_alpha_SH3. 

Pfam

 PF12026; DUF3513
 PF08824; Serine_rich
 PF00018; SH3_1 

SMART

 SM00326; SH3 

PROSITE

 PS50002; SH3 

PRINTS

 PR00452; SH3DOMAIN.
 PR01887; SPECTRNALPHA.