UniProt Accession

 DESM_HUMAN; P17661; Q15787; Q549R7; Q549R8; Q549R9; Q8IZR1; Q8IZR6; Q8NES2; Q8NEU6; Q8TAC4; Q8TCX2; Q8TD99; Q9UHN5; Q9UJ80 

Genbank Protein ID

 M63391; U59167; AF055081; AF055082; AF055083; AF137053; AF486807; AF487828; AF521879; AF527578; AY083345; AY114212; AY125465; BC032116; AJ132926 

Genbank Nucleotide ID

 AAA99221.1; AAC50680.1; AAC39938.1; AAC39939.1; AAC39940.1; AAF15400.1; AAL93205.1; AAL99078.1; AAN15036.1; AAN37810.1; AAL99215.1; AAM47026.1; AAM95238.1; AAH32116.1; CAB62389.1 

Protein Name

 Desmin 

Protein Synonyms/Alias

  

Gene Name

 DES 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
109	LTTRTNEKVELQELN	ubiquitination	[1]
240	NEEIAFLKKVHEEEI	acetylation	[2]

Reference

 [1] Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
 Xu G, Paige JS, Jaffrey SR.
 Nat Biotechnol. 2010 Aug;28(8):868-73. [PMID: 20639865]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. 

Sequence Annotation

 REGION 1 108 Head.
 REGION 109 412 Rod.
 REGION 109 141 Coil 1A.
 REGION 142 151 Linker 1.
 REGION 152 252 Coil 1B.
 REGION 253 268 Linker 12.
 REGION 269 287 Coil 2A.
 REGION 288 295 Linker 2.
 REGION 296 412 Coil 2B.
 REGION 413 470 Tail.
 MOD_RES 12 12 Phosphoserine; by AURKB.
 MOD_RES 17 17 Phosphothreonine; by AURKB.
 MOD_RES 58 58 ADP-ribosylarginine (By similarity).
 MOD_RES 60 60 Phosphoserine; by AURKB.  

Keyword

 ADP-ribosylation; Cardiomyopathy; Coiled coil; Complete proteome; Cytoplasm; Desmin-related myopathy; Disease mutation; Intermediate filament; Muscle protein; Myofibrillar myopathy; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 470 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005916; C:fascia adherens; IEA:Compara.
 GO:0005882; C:intermediate filament; TAS:ProtInc.
 GO:0031594; C:neuromuscular junction; IEA:Compara.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
 GO:0007010; P:cytoskeleton organization; TAS:ProtInc.
 GO:0030049; P:muscle filament sliding; TAS:Reactome.
 GO:0008016; P:regulation of heart contraction; TAS:ProtInc. 

Interpro

 IPR016044; F.
 IPR001664; IF.
 IPR006821; Intermed_filament_DNA-bd.
 IPR018039; Intermediate_filament_CS. 

Pfam

 PF00038; Filament
 PF04732; Filament_head 

SMART

  

PROSITE

 PS00226; IF 

PRINTS