CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000887
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glia maturation factor gamma 
Protein Synonyms/Alias
 GMF-gamma 
Gene Name
 GMFG 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
17VDPELTEKLRKFRFRubiquitination[1, 2]
20ELTEKLRKFRFRKETubiquitination[2]
25LRKFRFRKETDNAAIubiquitination[2]
35DNAAIIMKVDKDRQMacetylation[3]
35DNAAIIMKVDKDRQMubiquitination[1, 2]
38AIIMKVDKDRQMVVLubiquitination[1]
74RFVVYSYKYVHDDGRubiquitination[2]
97FSSPVGCKPEQQMMYubiquitination[2]
108QMMYAGSKNRLVQTAubiquitination[1, 2]
119VQTAELTKVFEIRTTacetylation[3]
119VQTAELTKVFEIRTTubiquitination[1, 2, 4, 5]
137TEAWLQEKLSFFR**ubiquitination[1, 2, 5]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
 DOMAIN 4 139 ADF-H.  
Keyword
 3D-structure; Complete proteome; Growth factor; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 142 AA 
Protein Sequence
MSDSLVVCEV DPELTEKLRK FRFRKETDNA AIIMKVDKDR QMVVLEEEFQ NISPEELKME 60
LPERQPRFVV YSYKYVHDDG RVSYPLCFIF SSPVGCKPEQ QMMYAGSKNR LVQTAELTKV 120
FEIRTTDDLT EAWLQEKLSF FR 142 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0008047; F:enzyme activator activity; TAS:ProtInc.
 GO:0004860; F:protein kinase inhibitor activity; TAS:ProtInc.
 GO:0006468; P:protein phosphorylation; TAS:ProtInc. 
Interpro
 IPR002108; Actin-bd_cofilin/tropomyosin.
 IPR011171; GMF-beta. 
Pfam
 PF00241; Cofilin_ADF 
SMART
 SM00102; ADF 
PROSITE
 PS51263; ADF_H 
PRINTS