CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007093
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dynamin-2 
Protein Synonyms/Alias
  
Gene Name
 Dnm2 
Gene Synonyms/Alias
 Dyn2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
240GVVNRSQKDIEGRKDacetylation[1]
299SLPTLRSKLQSQLLSacetylation[1]
598TEQRNVYKDLRQIELacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. 
Sequence Annotation
 DOMAIN 519 625 PH.
 DOMAIN 653 744 GED.
 NP_BIND 38 45 GTP (By similarity).
 NP_BIND 136 140 GTP (By similarity).
 NP_BIND 205 208 GTP (By similarity).
 MOD_RES 298 298 Phosphoserine (By similarity).
 MOD_RES 302 302 Phosphoserine (By similarity).
 MOD_RES 597 597 Phosphotyrosine (By similarity).
 MOD_RES 598 598 N6-acetyllysine (By similarity).
 MOD_RES 764 764 Phosphoserine; by CDK1.  
Keyword
 Acetylation; Alternative splicing; Cell junction; Cell membrane; Coated pit; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Endocytosis; GTP-binding; Hydrolase; Membrane; Microtubule; Motor protein; Nucleotide-binding; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 870 AA 
Protein Sequence
MGNRGMEELI PLVNKLQDAF SSIGQSCHLD LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 60
SGIVTRRPLI LQLIFSKTEY AEFLHCKSKK FTDFDEVRQE IEAETDRVTG TNKGISPVPI 120
NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIKDMI LQFISRESSL ILAVTPANMD 180
LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK 240
DIEGRKDIRA ALAAERKFFL SHPAYRHMAD RMGTPHLQKT LNQQLTNHIR ESLPTLRSKL 300
QSQLLSLEKE VEEYKNFRPD DPTRKTKALL QMVQQFGVDF EKRIEGSGDQ VDTLELSGGA 360
RINRIFHERF PFELVKMEFD EKDLRREISY AIKNIHGVRT GLFTPDLAFE AIVKKQVVKL 420
KEPCLKCVDL VIQELISTVR QCTSKLSSYP RLREETERIV TTYIREREGR TKDQILLLID 480
IEQSYINTNH EDFIGFANAQ QRSTQLNKKR AIPNQGEILV IRRGWLTINN ISLMKGGSKE 540
YWFVLTAESL SWYKDEEEKE KKYMLPLDNL KIRDVEKGFM SNKHVFAIFN TEQRNVYKDL 600
RQIELACDSQ EDVDSWKASF LRAGVYPEKD QAENEDGAQE NTFSMDPQLE RQVETIRNLV 660
DSYVAIINKS IRDLMPKTIM HLMINNTKAF IHHELLAYLY SSADQSSLME ESAEQAQRRD 720
DMLRMYHALK EALNIIGDIS TSTVSTPVPP PVDDTWLQNT SSHSPTPQRR PVSSVHPPGR 780
PPAVRGPTPG PPLIPMPVGA TSSFSAPPIP SRPGPQNVFA NNDPFSAPPQ IPSRPARIPP 840
GIPPGVPSRR APAAPSRPTI IRPAEPSLLD 870 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0045334; C:clathrin-coated endocytic vesicle; IDA:RGD.
 GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; ISS:UniProtKB.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0005525; F:GTP binding; TAS:RGD.
 GO:0003924; F:GTPase activity; TAS:RGD.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0032403; F:protein complex binding; IDA:RGD.
 GO:0006898; P:receptor-mediated endocytosis; IDA:RGD. 
Interpro
 IPR027188; DNM2.
 IPR022812; Dynamin.
 IPR000375; Dynamin_central.
 IPR001401; Dynamin_GTPase.
 IPR019762; Dynamin_GTPase_CS.
 IPR003130; GED.
 IPR020850; GTPase_effector_domain_GED.
 IPR027417; P-loop_NTPase.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF01031; Dynamin_M
 PF00350; Dynamin_N
 PF02212; GED
 PF00169; PH 
SMART
 SM00053; DYNc
 SM00302; GED
 SM00233; PH 
PROSITE
 PS00410; DYNAMIN
 PS51388; GED
 PS50003; PH_DOMAIN 
PRINTS
 PR00195; DYNAMIN.