UniProt Accession

 KLF10_HUMAN; Q13118; A8MVH0; B2R794; L0R4P6; L0R679; O75411; Q503B2 

Genbank Protein ID

 S81439; U21847; AF050110; AF050110; HF546210; HF546211; BT006634; AK312894; AP002851; CH471060; BC011538; BC095399 

Genbank Nucleotide ID

 AAB36088.1; AAC50340.1; AAC34293.1; AAC34294.1; CCO02796.1; CCO02797.1; AAP35280.1; BAG35741.1; EAW91850.1; AAH11538.1; AAH95399.1 

Protein Name

 Krueppel-like factor 10 

Protein Synonyms/Alias

 EGR-alpha; Transforming growth factor-beta-inducible early growth response protein 1; TGFB-inducible early growth response protein 1; TIEG-1 

Gene Name

 KLF10 

Gene Synonyms/Alias

 TIEG; TIEG1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
139	APFKEEEKSPVSAPK	ubiquitination	[1]
223	TVADVDEKASAALYD	ubiquitination	[1, 2]
356	GFSPSAAKVTPQIDS	ubiquitination	[1, 2, 3]
404	KPFSCSWKGCERRFA	ubiquitination	[2]
446	MRSDHLTKHARRHLS	ubiquitination	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'. 

Sequence Annotation

 ZN_FING 369 393 C2H2-type 1.
 ZN_FING 399 423 C2H2-type 2.
 ZN_FING 429 451 C2H2-type 3.
 MOD_RES 249 249 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 480 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030282; P:bone mineralization; IEA:Compara.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Compara.
 GO:0001501; P:skeletal system development; TAS:ProtInc.
 GO:0035019; P:somatic stem cell maintenance; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:ProtInc. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

  

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS