CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008511
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Low affinity cationic amino acid transporter 2 
Protein Synonyms/Alias
 CAT-2; CAT2; Solute carrier family 7 member 2 
Gene Name
 SLC7A2 
Gene Synonyms/Alias
 ATRC2; CAT2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
69LDSLEDTKLCRCLSTubiquitination[1]
488QPKCSPEKDGLGSSPubiquitination[1]
500SSPRVTSKSESQVTMubiquitination[1]
671VHAAAEEKSAIQANDubiquitination[1]
693SPFIFHEKTSEF***ubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Plays a regulatory role in classical or alternative activation of macrophages (By similarity). 
Sequence Annotation
 MOD_RES 455 455 Phosphoserine.
 MOD_RES 646 646 Phosphoserine.
 CARBOHYD 157 157 N-linked (GlcNAc...) (Potential).
 CARBOHYD 227 227 N-linked (GlcNAc...) (Potential).
 CARBOHYD 239 239 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Amino-acid transport; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 658 AA 
Protein Sequence
MKIETSGYNS DKLICRGFIG TPAPPVCDSK FLLSPSSDVR MIPCRAALTF ARCLIRRKIV 60
TLDSLEDTKL CRCLSTMDLI ALGVGSTLGA GVYVLAGEVA KADSGPSIVV SFLIAALASV 120
MAGLCYAEFG ARVPKTGSAY LYTYVTVGEL WAFITGWNLI LSYVIGTSSV ARAWSGTFDE 180
LLSKQIGQFL RTYFRMNYTG LAEYPDFFAV CLILLLAGLL SFGVKESAWV NKVFTAVNIL 240
VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG TSIYGAGGFM PYGFTGTLAG 300
AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF MAYFGVSAAL TLMMPYYLLD 360
EKSPLPVAFE YVGWGPAKYV VAAGSLCALS TSLLGSMFPL PRILFAMARD GLLFRFLARV 420
SKRQSPVAAT LTAGVISALM AFLFDLKALV DMMSIGTLMA YSLVAACVLI LRYQPGLSYD 480
QPKCSPEKDG LGSSPRVTSK SESQVTMLQR QGFSMRTLFC PSLLPTQQSA SLVSFLVGFL 540
AFLVLGLSVL TTYGVHAITR LEAWSLALLA LFLVLFVAIV LTIWRQPQNQ QKVAFMVPFL 600
PFLPAFSILV NIYLMVQLSA DTWVRFSIWM AIGFLIYFSY GIRHSLEGHL RDENNEEDAY 660
PDNVHAAAEE KSAIQANDHH PRNLSSPFIF HEKTSEF 697 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0015174; F:basic amino acid transmembrane transporter activity; TAS:ProtInc.
 GO:0005289; F:high affinity arginine transmembrane transporter activity; IEA:Compara.
 GO:0015189; F:L-lysine transmembrane transporter activity; IEA:Compara.
 GO:0000064; F:L-ornithine transmembrane transporter activity; IEA:Compara.
 GO:0006520; P:cellular amino acid metabolic process; TAS:ProtInc.
 GO:0042116; P:macrophage activation; IEA:Compara.
 GO:0006809; P:nitric oxide biosynthetic process; IEA:Compara.
 GO:0002537; P:nitric oxide production involved in inflammatory response; IEA:Compara.
 GO:0050727; P:regulation of inflammatory response; IEA:Compara.
 GO:0043030; P:regulation of macrophage activation; IEA:Compara. 
Interpro
 IPR002293; AA/rel_permease1.
 IPR015606; Cat-AATrans.
 IPR004755; Cat_AA_permease. 
Pfam
  
SMART
  
PROSITE
  
PRINTS