CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008429
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 H(+)/Cl(-) exchange transporter 7 
Protein Synonyms/Alias
 Chloride channel 7 alpha subunit; Chloride channel protein 7; ClC-7 
Gene Name
 CLCN7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
88KEIPHNEKLLSLKYEubiquitination[1]
93NEKLLSLKYESLDYDubiquitination[2]
274TSLKRDFKIFEYFRRubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen. 
Sequence Annotation
 DOMAIN 631 695 CBS 1.
 DOMAIN 741 799 CBS 2.
 NP_BIND 658 660 ATP (By similarity).
 NP_BIND 783 786 ATP (By similarity).
 MOTIF 203 207 Selectivity filter part_1 (By
 MOTIF 245 249 Selectivity filter part_2 (By
 MOTIF 512 516 Selectivity filter part_3 (By
 BINDING 204 204 Chloride (By similarity).
 BINDING 514 514 Chloride; via amide nitrogen (By
 BINDING 602 602 Chloride (By similarity).  
Keyword
 Alternative splicing; Antiport; ATP-binding; CBS domain; Chloride; Complete proteome; Disease mutation; Ion transport; Lysosome; Membrane; Nucleotide-binding; Osteopetrosis; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 805 AA 
Protein Sequence
MANVSKKVSW SGRDRDDEEA APLLRRTARP GGGTPLLNGA GPGAARQSPR SALFRVGHMS 60
SVELDDELLD PDMDPPHPFP KEIPHNEKLL SLKYESLDYD NSENQLFLEE ERRINHTAFR 120
TVEIKRWVIC ALIGILTGLV ACFIDIVVEN LAGLKYRVIK GNIDKFTEKG GLSFSLLLWA 180
TLNAAFVLVG SVIVAFIEPV AAGSGIPQIK CFLNGVKIPH VVRLKTLVIK VSGVILSVVG 240
GLAVGKEGPM IHSGSVIAAG ISQGRSTSLK RDFKIFEYFR RDTEKRDFVS AGAAAGVSAA 300
FGAPVGGVLF SLEEGASFWN QFLTWRIFFA SMISTFTLNF VLSIYHGNMW DLSSPGLINF 360
GRFDSEKMAY TIHEIPVFIA MGVVGGVLGA VFNALNYWLT MFRIRYIHRP CLQVIEAVLV 420
AAVTATVAFV LIYSSRDCQP LQGGSMSYPL QLFCADGEYN SMAAAFFNTP EKSVVSLFHD 480
PPGSYNPLTL GLFTLVYFFL ACWTYGLTVS AGVFIPSLLI GAAWGRLFGI SLSYLTGAAI 540
WADPGKYALM GAAAQLGGIV RMTLSLTVIM MEATSNVTYG FPIMLVLMTA KIVGDVFIEG 600
LYDMHIQLQS VPFLHWEAPV TSHSLTAREV MSTPVTCLRR REKVGVIVDV LSDTASNHNG 660
FPVVEHADDT QPARLQGLIL RSQLIVLLKH KVFVERSNLG LVQRRLRLKD FRDAYPRFPP 720
IQSIHVSQDE RECTMDLSEF MNPSPYTVPQ EASLPRVFKL FRALGLRHLV VVDNRNQVVG 780
LVTRKDLARY RLGKRGLEEL SLAQT 805 
Gene Ontology
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005765; C:lysosomal membrane; TAS:Reactome.
 GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005254; F:chloride channel activity; TAS:ProtInc.
 GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
 GO:0009268; P:response to pH; IEA:Compara. 
Interpro
 IPR014743; Cl-channel_core.
 IPR001807; Cl-channel_volt-gated.
 IPR002249; Cl_channel-7.
 IPR000644; Cysta_beta_synth_core. 
Pfam
 PF00571; CBS
 PF00654; Voltage_CLC 
SMART
 SM00116; CBS 
PROSITE
 PS51371; CBS 
PRINTS
 PR00762; CLCHANNEL.
 PR01118; CLCHANNEL7.