| Tag | Content |
|---|
| CPLM ID | CPLM-011273 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cytokinesis protein 2 |
Protein Synonyms/Alias | Homolog of CDC15 protein 1 |
Gene Name | HOF1 |
Gene Synonyms/Alias | CYK2; YMR032W; YM9973.05 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 467 | DDSQRFAKSWNSSNR | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Throughout most of the cell cycle it forms a double ring that coincides with the septins. After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Mediates cytoskeletal rearrangements required for cytokinesis. In conjunction with the medial actin ring exhibits contraction-like action. |
Sequence Annotation | DOMAIN 1 69 FCH.
DOMAIN 599 667 SH3.
MOD_RES 337 337 Phosphoserine.
MOD_RES 366 366 Phosphoserine.
MOD_RES 421 421 Phosphoserine. |
Keyword | Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Mitosis; Phosphoprotein; Reference proteome; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 669 AA |
Protein Sequence | MSYSYEACFW DPNDNGVNIL LGHISQGIRS CDSMILFFKQ RSELEKDYAR RLGAITGKLD 60
KDIGTNMDYG KLNETFNVVL SVEKARAQSH SKQSEILFRQ IYTDTKAFAA NLQARYTTLS 120
GKIERLRMDK FNKKKGCEVL QKKLQDAQIR FRDLQLNENN MIGAKRVEHN KRELLKWESN 180
SQEYKVQLDV LKQEYKASQK FWIHEWAQLS CELQEMENAR ISFLQSKLQQ FATSSMETYI 240
LEQTKMDMLT NHLNSFTAAD EISTFSKENG TGRLKHKTSK GDMNSSANWA QMSSISTTSK 300
KTESYMDNIR KLSSQLKETE NKRKLASIDK YEKPLPSPEV TMATQFRNST PVIRNETKVV 360
ANPTLSLRSS PVQLQSNVDD SVLRQKPDKP RPIVGEEQLK PDEDSKNPDE KGLMVHKRNQ 420
SLSSPSESSS SNPTDFSHIK KRQSMESMTT SVSSMANSID DSQRFAKSWN SSNRKRKSMS 480
HLQVPSSASS RSDDGGRTPN SAHNLNEDDY NTRRDTSTST ILFKPPVAVR GTSRGHTHRQ 540
SMIMQDSSNP IEDALYEMER IQSSSKPGTK TGNIMDERGV VRDRGITVTL PIVTSEGFPV 600
IEYAKAMYPL IGNEAPGLAN FHKGDYLLIT EIVNKDWYKG EVYDNDRIDR NHRIGLIPYN 660
FIQLLHQGL 669 |
Gene Ontology | |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |