UniProt Accession

 NOP10_HUMAN; Q9NPE3 

Genbank Protein ID

 AB043103; AB043104; BC008886; BC063023 

Genbank Nucleotide ID

 BAA96107.1; BAA96133.1; AAH08886.1; AAH63023.1 

Protein Name

 H/ACA ribonucleoprotein complex subunit 3 

Protein Synonyms/Alias

 Nucleolar protein 10; Nucleolar protein family A member 3; snoRNP protein NOP10 

Gene Name

 NOP10 

Gene Synonyms/Alias

 NOLA3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
40	ARFSPDDKYSRHRIT	acetylation	[1]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 

Functional Description

 Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. 

Sequence Annotation

  

Keyword

 Complete proteome; Disease mutation; Dyskeratosis congenita; Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 64 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005732; C:small nucleolar ribonucleoprotein complex; TAS:UniProtKB.
 GO:0001522; P:pseudouridine synthesis; NAS:UniProtKB.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR007264; H/ACA_rnp_Nop10. 

Pfam

 PF04135; Nop10p 

SMART

  

PROSITE

  

PRINTS