CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027351
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Erythrocyte membrane protein 1, PfEMP1 
Protein Synonyms/Alias
  
Gene Name
 VAR 
Gene Synonyms/Alias
 PFL1960w 
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
22DAKELLDKIGQQVHDacetylation[1]
30IGQQVHDKVKSESNGacetylation[1]
32QQVHDKVKSESNGFKacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2359 AA 
Protein Sequence
MGPPSTAPDY SSAKDAKELL DKIGQQVHDK VKSESNGFKD ELEGSLSLAK VSGVELADTL 60
DPCKLIKEKH ENLIGARGDP CGKDGTGKED DSKRFSKESG AECDEKKIKD NKSKGGNNEG 120
ACAPYRRLSL CNKNMEKMGR TSTTKHDLLL DVCMAANYEA ESLIPYHDQY EATYKDYGST 180
MCTMLARSFA DIGDIIRGRD LYSGNKVKKK KLDDSLKTIF GKIYEGLTGG VKERYTNDGG 240
DFFQLREDWW TANRETVWKA MTCSEHLKNS AYFRVTCSDK QGESIANHKC RCPMTSDGKP 300
NDQVPTYFDY VPQYLRWFEE WAEDFCRKKK IYVGIVKKYC LDETEEKYCS LNGCDCTQTV 360
RAKGKLRYGN RCTDCLFACH RYEKWIDNQR KQFLKQRNKY ADEIKKYINE ASSSSGSGRQ 420
RRGARNENYD GYESKFYDIL KNKRYENVDA FLGLLNNEKA CQAVTDDKGG RINFKNVNSG 480
KNSGGGESGD RGKGASSTSD TSGTNDETKG TFYRSKYCQP CPICGMKKKG GKWEAKNDDK 540
CKRGKLYEPT SSAKPTEIKI LKSGENHDDI EKKLEAFCET QNRSDGSSSV HVGGGSGGGG 600
GSGGGGGSGG GGGSGGGGGS GGGGGSGGGG GSGGGGGSGG GGGSGGGGGS GGGGGSGGGG 660
GSGGGGGSGG GGGSGGGGGS GGGGGSGGGG GSGSKSDSQK LYEEWKCYKH DEVQKVQGQG 720
EEEDEDEVEE EDDLKSAGGL CILPNPKKKE ESEAKSQNEP EQFQKTFYDF FTYWVAHMLK 780
DSIHWRTEKL DKCINNTNGK QTKCRKGCKG DCDCFLKWVN EKKTEWGKIK DHFKTQEGLD 840
NEGENGIPES TRFGFTHDVV LGEFLELQFL NENNEENSKN SLDSEEIKHL KNLRDIIKKK 900
NQQAGAGATG KRTIMDELID YEEGIAKDCQ QKCQETQKPQ QVDRDLARSA TGPRDPSSPA 960
APTAGPVESA AVDDEDDDNE EEEEEEEEED EKEEVGGSDV VEEKEEKEEE KEPEEQVEPQ 1020
PAATTTQNDV KVCDTVDKLF KDTTALQDAC NLKYVKGKNY GWRCVAPSHT TSETTGKSES 1080
ATSSSGATTA PAPSLTSPQA TASANSANSV SSAVCIPPRR RRLYVGKLEQ WASGGNTQGG 1140
GGNTQVTPQA GGSEAQTQPQ GKDAASTSPQ VALLRDAFIQ SAAIETFFLW HKYKMEKKKE 1200
KEETQGQVYK QTDDEDKTPQ ELLNSGKIPD GFLRQMFYTL ADYKDILFSG DKDKKNGYSD 1260
IINGDKEMKA KEEKIKEAIQ KFFEQTRGAI PPPPSGTTPS SWWEQHAESI WNGMICALTY 1320
TDNSDTVAKG KASITQDTDL KDALWDENGA TNEPIKYKYT EATASGDNTP LTQFVLRPPY 1380
FRYLEEWGET FCRQRTRMLA KIRGECVKSG SERCSGDGED CNDQLDADPT IVRDFLCSTC 1440
GRHCSFYKKW IQRKKEEFTE QYNAYGGQKT KCQTESETAK EFCGTLNTFN DAAKFLERLK 1500
SGPCKNNENV EDNGKDKLDF SKPNETFVPA TNCKPCSSFK IDCKKAKCSN RDDTNVGFNC 1560
KKNGNGYITS DHIKNEDNFT DTIDMLVSDD NKNKSETVLE ACEGADIFEG IKENKWKCGN 1620
VCGYVVCKPE NGNGKIVNGK PNGENQIIII RALFKRWLEY FLEDYNKIRK KLKPCMNNSD 1680
GSPCIDNYKK KYQCVLQWIS RKEEEWKKIK EHYEKQKPKN GDNNMKSLVT DILSGLYPQT 1740
DVNKAIKPCK GLTKFESFCG LNRTESSKIK DGTPKDVVEC LFQKIQKKIE ECKQKHPQPS 1800
ANNCTTSPTS DTPPDDEEDL LHEEEENQVK APEICPTPQQ EPEAEDEGEC KAASPATSEE 1860
QTNQTSNPHE TPVLKPEEEA TAPTSPPRPP LVTSTLAWSV GIGFAAFTYF YLKKKTKSSV 1920
GNLFQILQIP KGDYDIPTLK STNRYIPYAS DRHKGKTYIY MEGDTSGDED KYAFMSDTTD 1980
VTSSESEYEE LDINDIYVPG SPKYKTLIEV VLEPSKRDTQ NDMPSDDIPS DIPNSDTPPP 2040
ITDDEWNQLK KDFISNMLQN TQNTEPNILR DNVDNNTHPT PSRHTLDQKP FIMSIHDRNL 2100
LNGEEYNYDM STNSGENNVY SGIDPTSDNR DPYSDKKDPI SGTKDPISDN HHPYSGIDLI 2160
NAALNGDYDL YDEILKRKEN ELFGTNHVKQ TSTHSVAKNT NSDPVMNQLD LFHKWLDRHR 2220
DMCEKWDTNN KKEELLDKLK EEWNKDNNKH NGENTINKTL NTDVSIHIHM DDPKPTNEFS 2280
NMDTYPNNSS MDNILDDLEK YNEPYYDVQD DIYYDVNDHD ASTVDSNNMD VPSKVKLEMS 2340
VKNTQMMEEK YPIGDVWDI 2359 
Gene Ontology
 GO:0020002; C:host cell plasma membrane; TAS:GeneDB_Pfalciparum.
 GO:0020030; C:infected host cell surface knob; TAS:GeneDB_Pfalciparum.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0050839; F:cell adhesion molecule binding; TAS:GeneDB_Pfalciparum.
 GO:0046789; F:host cell surface receptor binding; TAS:GeneDB_Pfalciparum.
 GO:0004872; F:receptor activity; IEA:InterPro.
 GO:0020033; P:antigenic variation; TAS:GeneDB_Pfalciparum.
 GO:0020035; P:cytoadherence to microvasculature, mediated by symbiont protein; TAS:GeneDB_Pfalciparum.
 GO:0020013; P:modulation by symbiont of host erythrocyte aggregation; TAS:GeneDB_Pfalciparum.
 GO:0009405; P:pathogenesis; IEA:InterPro. 
Interpro
 IPR008602; Duffy-antigen_binding.
 IPR004258; PFEMP. 
Pfam
 PF05424; Duffy_binding
 PF03011; PFEMP 
SMART
  
PROSITE
  
PRINTS