CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034463
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mitochondrial 10-formyltetrahydrofolate dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 Aldh1l2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
64LQRSCDVKPNDTVDSacetylation[1, 2, 3]
64LQRSCDVKPNDTVDSsuccinylation[3]
114ATYEGIQKKENAEVSacetylation[1, 2, 3]
114ATYEGIQKKENAEVSsuccinylation[3]
505AGNTLVLKPAQVTPLacetylation[1]
568SVGKQIMKSCAVSNLacetylation[1, 3]
568SVGKQIMKSCAVSNLsuccinylation[3]
576SCAVSNLKKVSLELGacetylation[3]
576SCAVSNLKKVSLELGsuccinylation[3]
577CAVSNLKKVSLELGGubiquitination[4]
598FSDCDLEKAVRMGMGacetylation[1]
611MGAVFFNKGENCIAAacetylation[2]
790MKQSGFGKDLGEEALacetylation[1, 2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Oxidoreductase; Phosphopantetheine; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 810 AA 
Protein Sequence
MDVIDSPKHG SIIYHPSLLP RHRGASAINW TLIMGDKKAG FSVFWADDGL DTGPILLQRS 60
CDVKPNDTVD SLYNRFLFPE GIKAMVEAVQ LIADGKAPRT PQPEEGATYE GIQKKENAEV 120
SWDQPAEGLH NWIRGHDKVP GAWAEINGQM VTFYGSSLLT SSVPSGEPLD IRGAKKPGLV 180
TKNGLVLFGN DGKALMVRNL QFEDGKMIPA SQYFSAGETS VVELTAEELK VAETIKVIWA 240
RILSNTPVIE DSTDFFKSGA SSMDVVRLVE EIRQSCGGLQ LQNEDVYMAT KFGDFIQKVV 300
RRLRGEDEEA EMVVDYVSKE VNGMTVKIPY QCFINGQFVD AEDGETYATV NPTDGTTICR 360
VSYASLADVD RAVAAAKDAF ENGEWGRMNA RDRGRLMYRL ADLMEENQEE LATIEALDSG 420
AVYTLALKTH IGMSVQTFRY FAGWCDKIQG STIPINQARP NYNLTFTKKE PLGACAIIIP 480
WNYPLMMLAW KSAACLAAGN TLVLKPAQVT PLTALKFAEL TVKAGFPKGV INIIPGSGGV 540
AGQRLSQHPD IRKLGFTGST SVGKQIMKSC AVSNLKKVSL ELGGKSPLII FSDCDLEKAV 600
RMGMGAVFFN KGENCIAAGR LFVEEAIHDE FVTRVVEEIK KMKIGDPLDR STDHGPQNHR 660
AHLEKLLQYC ETGVQEGATL VYGGRQVQRP GFFMEPTVFT GVEDHMYLAK EESFGPIMVI 720
SKFQNGDIDG VLQRANNTEY GLASGVFTRD INKAMYVSDK LEAGTVFINT YNKTDVAAPF 780
GGMKQSGFGK DLGEEALNEY LKIKTVTLEY 810 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0016742; F:hydroxymethyl-, formyl- and related transferase activity; IEA:InterPro.
 GO:0008168; F:methyltransferase activity; IEA:InterPro.
 GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
 GO:0009058; P:biosynthetic process; IEA:InterPro.
 GO:0032259; P:methylation; IEA:GOC. 
Interpro
 IPR009081; Acyl_carrier_prot-like.
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR005793; Formyl_trans_C.
 IPR002376; Formyl_transf_N.
 IPR011034; Formyl_transferase_C-like.
 IPR001555; GART_AS.
 IPR006162; PPantetheine_attach_site. 
Pfam
 PF00171; Aldedh
 PF02911; Formyl_trans_C
 PF00551; Formyl_trans_N
 PF00550; PP-binding 
SMART
  
PROSITE
 PS50075; ACP_DOMAIN
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU
 PS00373; GART
 PS00012; PHOSPHOPANTETHEINE 
PRINTS