CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039742
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mediator of RNA polymerase II transcription subunit 15 
Protein Synonyms/Alias
  
Gene Name
 MED15 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
427DILTDPSKRCPLKTLubiquitination[1, 2]
Reference
 [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 637 AA 
Protein Sequence
MESHVFLKAK TRDEYLSLVA RLIIHFRDIH NKKSQASVSA QLQLQQVALQ QQQQQQQFQQ 60
QQQAALQQQQ QQQQQQQFQA QQSAMQQQFQ AVVQQQQQLQ QQQQQQQHLI KLHHQNQQQI 120
QQQQQQLQRI AQLQLQQQQQ QQQQQQQQQQ QALQAQPPIQ QPPMQQPQPP PSQALPQQLQ 180
QMHHTQHHQP PPQPQQPPVA QNQPSQLPPQ SQTQPLVSQA QALPGQMLYT QPPLKFVRAP 240
MVVQQPPVQP QVQQQQTAVQ TAQAAQMVAP GVQVSQSSLP MLSSPSPGQQ VQTPQSMPPP 300
PQPSPQPGQP SSQPNSNVSS GPAPSPSSFL PSPSPQPSQS PVTARTPQNF SVPSPGPLNT 360
PVNPSSVMSP AGSSQAEEQQ YLDKLKQLSK YIEPLRRMIN KIDKNEDRKK DLSKMKSLLD 420
ILTDPSKRCP LKTLQKCEIA LEKLKNDMAV PTPPPPPVPP TKQQYLCQPL LDAVLANIRS 480
PVFNHSLYRT FVPAMTAIHG PPITAPVVCT RKRRLEDDER QSIPSVLQGE VARLDPKFLV 540
NLDPSHCSNN GTVHLICKLD DKDLPSVPPL ELSVPADYPA QSPLWIDRQW QYDANPFLQS 600
VHRCMTSRLL QLPDKHSVTA LLNTWAQSVH QACLSAA 637 
Gene Ontology
 GO:0016592; C:mediator complex; IEA:InterPro.
 GO:0001104; F:RNA polymerase II transcription cofactor activity; IEA:InterPro. 
Interpro
 IPR019087; Mediator_Med15_met. 
Pfam
 PF09606; Med15 
SMART
  
PROSITE
  
PRINTS