UniProt Accession

 HSP12_YEAST; P22943; D6VTL5; Q8X145 

Genbank Protein ID

 M60827; X55785; Z46255; D50617; D89864; AY046957; AY558464; BK006940 

Genbank Nucleotide ID

 AAA34647.1; CAA39306.1; CAA86349.1; BAA09224.1; BAA14033.1; AAL06077.1; AAS56790.1; DAA12425.1 

Protein Name

 12 kDa heat shock protein 

Protein Synonyms/Alias

 Glucose and lipid-regulated protein 

Gene Name

 HSP12 

Gene Synonyms/Alias

 GLP1; HOR5; YFL014W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
12	GRKGFGEKASEALKP	acetylation	[1]
12	GRKGFGEKASEALKP	ubiquitination	[2]
18	EKASEALKPDSQKSY	acetylation	[1]
18	EKASEALKPDSQKSY	ubiquitination	[2]
23	ALKPDSQKSYAEQGK	acetylation	[1]
23	ALKPDSQKSYAEQGK	ubiquitination	[2]
30	KSYAEQGKEYITDKA	acetylation	[1]
30	KSYAEQGKEYITDKA	ubiquitination	[2]
36	GKEYITDKADKVAGK	acetylation	[1]
43	KADKVAGKVQPEDNK	acetylation	[1]
43	KADKVAGKVQPEDNK	ubiquitination	[2]
50	KVQPEDNKGVFQGVH	ubiquitination	[2, 3]
62	GVHDSAEKGKDNAEG	acetylation	[1]
64	HDSAEKGKDNAEGQG	ubiquitination	[2]
86	RDYMGAAKSKLNDAV	ubiquitination	[2]
88	YMGAAKSKLNDAVEY	acetylation	[1]
88	YMGAAKSKLNDAVEY	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 

Functional Description

 May play a role in a switch from carbohydrate utilizing metabolism to fatty acid utilizing metabolism. 

Sequence Annotation

 MOD_RES 21 21 Phosphoserine; by ATM or ATR.
 MOD_RES 24 24 Phosphoserine.
 MOD_RES 59 59 Phosphoserine.
 MOD_RES 73 73 Phosphoserine.
 MOD_RES 97 97 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 109 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005768; C:endosome; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0008289; F:lipid binding; IDA:SGD.
 GO:0007155; P:cell adhesion; IDA:SGD.
 GO:0034605; P:cellular response to heat; IMP:SGD.
 GO:0071470; P:cellular response to osmotic stress; IMP:SGD.
 GO:0034599; P:cellular response to oxidative stress; IMP:SGD.
 GO:0007009; P:plasma membrane organization; IMP:SGD. 

Interpro

 IPR016360; Heat_shock_protein_9/12_fun.
 IPR007250; HSP9_HSP12. 

Pfam

 PF04119; HSP9_HSP12 

SMART

  

PROSITE

  

PRINTS