CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013716
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Trigger factor 
Protein Synonyms/Alias
 TF; PPIase 
Gene Name
 tig 
Gene Synonyms/Alias
 GK2653 
Created Date
 July 27, 2013 
Organism
 Geobacillus kaustophilus (strain HTA426) 
NCBI Taxa ID
 235909 
Lysine Modification
Position
Peptide
Type
References
398KLSVDKLKELLGSLDacetylation[1]
Reference
 [1] Proteomic analysis of acetylation in thermophilic Geobacillus kaustophilus.
 Lee DW, Kim D, Lee YJ, Kim JA, Choi JY, Kang S, Pan JG.
 Proteomics. 2013 Aug;13(15):2278-82. [PMID: 23696451] 
Functional Description
 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity). 
Sequence Annotation
 DOMAIN 163 248 PPIase FKBP-type.  
Keyword
 Cell cycle; Cell division; Chaperone; Complete proteome; Cytoplasm; Isomerase; Rotamase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 428 AA 
Protein Sequence
MSVKWEKLEG NEGVLTVEVD AEKVNKGLDA AFKKVVKNIT LPGFRKGKVP RVLFEKRFGV 60
EALYQDALDI LLPEAYAKAV EEAGIEPVSM PEIDIEQMEK GKSLIFKAKV TVKPEVKLGQ 120
YKGLEVEKMD TTVTDEDVEN ELKRLQEDYA ELVVKEDGTV ENGDTVVIDF EGFVDGEPFE 180
GGKAENYSLE IGSGTFIPGF EEQLVGMKAG EEKEIQVTFP DEYHAKQLAG KPATFKVKVH 240
EVKAKQLPAL DDEFAKDVDE EVETLDELKA KIRARLEEAK KNEAETALRN AVVEKAAANA 300
EMDIPEVMIK NETDRMLREF DQRLQMQGLN LQLYYQFSGQ DEASLREQMK EDAEKRVRAA 360
LTLEAIAKAE NIEVTDEEVN KELEKMAEAY KLSVDKLKEL LGSLDGVKED LKWRKTVDFL 420
VEHSKVAA 428 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:HAMAP.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:HAMAP.
 GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC.
 GO:0015031; P:protein transport; IEA:HAMAP. 
Interpro
 IPR001179; PPIase_FKBP_dom.
 IPR005215; Trig_fac.
 IPR008880; Trigger_fac_C.
 IPR008881; Trigger_fac_ribosome-bd_bac.
 IPR027304; Trigger_fact/SurA_dom. 
Pfam
 PF00254; FKBP_C
 PF05698; Trigger_C
 PF05697; Trigger_N 
SMART
  
PROSITE
 PS50059; FKBP_PPIASE 
PRINTS