| Tag | Content |
|---|
| CPLM ID | CPLM-018549 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Oxysterol-binding protein-related protein 1 |
Protein Synonyms/Alias | ORP-1; OSBP-related protein 1 |
Gene Name | Osbpl1a |
Gene Synonyms/Alias | Orp1; Orp1a; Orp1l |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 623 | SQWERTGKPFNPLLG | ubiquitination | [1] | | 682 | PKLKFWGKSVEAEPK | ubiquitination | [1] | | 763 | VEGYIQDKSKKKLCA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (By similarity). |
Sequence Annotation | REPEAT 47 76 ANK 1.
REPEAT 80 109 ANK 2.
REPEAT 175 204 ANK 3.
DOMAIN 235 334 PH.
REGION 1 237 Interaction with RAB7A (By similarity).
MOD_RES 499 499 Phosphoserine (By similarity). |
Keyword | Alternative splicing; ANK repeat; Coiled coil; Complete proteome; Direct protein sequencing; Endosome; Lipid transport; Lipid-binding; Phosphoprotein; Reference proteome; Repeat; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 950 AA |
Protein Sequence | MNTEAEQQLL HHARNGNAEE VRKLLAAMAR MEVVADIDCK GRSKSNLGWT PLHLACYFGH 60
KQVVEDLLKA GAKVNMLNDM GDTPLHRAAF TGRKELVLLL LEYDADSTVV NGSGQTAKEA 120
THDKEIRNML EAVERTQQRK LEELLLGAAR EGRTAEVSAL LSRPNPPDVN CSDQLGNTPL 180
HCAAYRAHKQ CVLKLLRSGA DPSLKNKNDQ KPLDLAQGAE MKHILVGNKV VHKALKRYEG 240
PLWKSSRFFG WKLFWVVLEH GVLSWYRKQP DAVHNSYRQG CKHLTQAVCT VKPTDSCLFS 300
IRCFDDTVHC FRVPKNSVQQ SREKWLEAIE EHSAYSTHYC SQDQVTDDEE EDVVSAMDLK 360
ESLARAQTCQ QRLDREIYNF LKMIKECDVA KDMLPSFLQK ADIVSEASRE TCVALNDCLN 420
LFTKQEGVRN FKLEQEQEKN KILSEALETL ATEHHELERS LVEGSPPVSI LSEEEFYDAL 480
SGSESEGSLT CLEAVTAHSF EENEVPGSSG KHRMSEGKDC GGGDALSNGI KKHRTSLPSP 540
MFSRNDFSIW SILRKCIGME LSKITMPVIF NEPLSFLQRL TEYMEHTYLI HKASSLSDPV 600
ERMQCVAAFA VSAVASQWER TGKPFNPLLG ETYELVRDDL GFRLISEQVS HHPPISAFHA 660
EGLNNDFIFH GSIYPKLKFW GKSVEAEPKG TITLELLDHN EAYTWTNPTC CVHNIIVGKL 720
WIEQYGNVEI INHKTGDKCV LNFKPCGLFG KELHKVEGYI QDKSKKKLCA LYGKWTECLY 780
SVDPATFDAY KKNDKKNTEE KKNSKQTSSS EESDEMPVPD SESVFIIPGS VLLWRIAPRP 840
PNSAQMYNFT SFAMVLNEVD KEMESVIPKT DCRLRPDIRA MENGEIDLAS EEKKRLEEKQ 900
RAARKNRSKS EEDWKTRWFH QGPNPYSGAQ DWIYSGSYWD RNYFNLPDIY 950 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |