| Tag | Content |
|---|
| CPLM ID | CPLM-014799 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Myoferlin |
Protein Synonyms/Alias | Fer-1-like protein 3 |
Gene Name | Myof |
Gene Synonyms/Alias | Fer1l3; Kiaa1207 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1433 | LASKLSEKEEEIVDW | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR. |
Sequence Annotation | DOMAIN 1 85 C2 1.
DOMAIN 186 281 C2 2.
DOMAIN 345 458 C2 3.
DOMAIN 1113 1218 C2 4.
DOMAIN 1525 1625 C2 5.
REGION 186 281 Necessary for interaction with EHD2 (By
MOD_RES 174 174 Phosphoserine.
MOD_RES 871 871 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Alternative splicing; Cell membrane; Complete proteome; Cytoplasmic vesicle; Membrane; Nucleus; Phosphoprotein; Reference proteome; Repeat; Signal-anchor; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2048 AA |
Protein Sequence | MLRVIVESAT NIPKTKFGKP DPIVSVIFKD EKKKTKKVDN ELNPVWNEIL EFDLRGIPLD 60
SSSSLVIVVK DFETIGQNKL IGTATVSLKD LIGDQNRSLP YKQTSLLNEK GQDTGATIDL 120
VIGYTPPSAP HPNDPSGTSV PGMGEEEEED QGDEDRVDGI VRGPGPKGPS GTVSEAQLAR 180
RITKGKSSRR MLSNKPQDFQ IRVRVIEGRQ LCGNNIRPVV KVHICGQTHR TRIKRGNNPF 240
FDELFFYNVH ITPSELMDEI ISIRVYNSHS LRADCLMGEF KIDVGFVYDE PGHAVMRKWL 300
LLNDPEDTSS GAKGYMKVSM FVLGTGDEPP PEKRDRDNDS DDVESNLLLP AGIALRWVTF 360
MLKIYRAEDI PQMDDAFSQT VKEIFGGNAD KKNLVDPFVE VSFAGKKVCT NIIERNANPE 420
WNQVVNLQIK FPSMCEKIKL TVYDWDRLTK NDVVGTTYLY LSKIAASGGE VEATTGETEV 480
GFVPTFGPCY LNLYGSPREY TGFPDPYDEL NSGKGEGVAY RGRIFVELNT FLEKKPPEKK 540
LEPISSDDLL VVEKYQRRRK YSLSAVFHSA TMLQDVGEAI QFEVSIGNYG NKFDATCKPL 600
ASTTQYSRAV FDGNYYYYLP WAHTKPVVTL TSYWEDISHR LDAVNTLLVM AERLQSNIEA 660
VKSGIQGKIP ANQLAEVWLK LIDEVIEDTR YTLPVTEGKA NVTVLDTQIR KLRSRFLSQI 720
HEAALRMRSE ATDVKSTLLE IEEWLDKLMQ LTEEPQNSMP DIIIWMIRGE KRLAYARIPA 780
HQVLYSTSGG NASGKYCGKT QTILLKYPQE KTNGPKVPVE LRVNIWLGLS AVEKKFNSFA 840
EGTFTVFAEM YENQALVFGK WGTSGLVGRH KFSDVTGKIK LKREFFLPPK GWEWEGDWVV 900
DPERSLLTEA DAGHTEFTDE VYQNENRYPG GEWKQAEDTY TDANGDKAAS PSEMTCPPGW 960
EWEDDAWIYD INRAVDEKGW EYGITIPPDN KPKSWVAAEK MYHTHRRRRL VRKRKKDLTQ 1020
TASSTARAME ELEDREGWEY ASLIGWKFHW KQRSSDTFRR RRWRRKMAPS ETHGAAAIFK 1080
LEGALGADTT EDGEEKGPEK QKHSATTVFG ANTPIVSCNF DRVYIYHLRC YIYQARNLMA 1140
LDKDSFSDPY AHVSFLHRSK TTEIIHSTLN PTWDQTIIFD EVEIFGEPQT VLQNPPNVTI 1200
ELFDNDQVGK DEFLGRSICS PLVKLNSETD ITPKLLWHPV MNGDKACGDV LVTAELILRN 1260
KDGSNLPILP SQRAPNLYMV PQGIRPVVQL TAIEILAWGL RNMKNYQMAS VTSPSLVVEC 1320
GGERVESVVI KSLKKTPNFP SSVLFMKVFL PKEELYMPPL VIKVIDHRQF GRKPVVGQCT 1380
IDHLDRFRCD PYAGKEDIVP QLKASLMSAP PCREVVIEIE DTKPLLASKL SEKEEEIVDW 1440
WSKFYASSGE HEKCGQYIQK GYSKLKIYDC ELEDVADFEG LTDFSDTFKL YRGKSDENED 1500
PSVVGEFKGS FRIYPLPDDP SVPAPPRQFR ELPDSVPQEC TVRIYIVQGL QLQPQDNNGL 1560
CDPYIKITLG KKVIEDRDHY IPNTLNPVFG RMYELSCYLP QEKDLKISVY DYDTFTRDEK 1620
VGETTIDLEN RFLSRFGSHC GIPEQYCVSG VNTWRDQLRP TQLLQNVARF KGFPPPVLSE 1680
DGSRIRYGGR DYHLDEFEAN KILHQHLGAP EERLALHILR TQGLVPEHVE TRTLHSTFQP 1740
NISQGKLQMW VDVFPKSLGP PGPPFNITPR KAKKYYLRVI IWNTKDVILD EKSITGEDMS 1800
DIYVKGWISG SEENKQKTDV HYRSLDGEGN FNWRFVFPFD YLPAEQLCIV AKKEHFWSID 1860
QTEFRVPPRL IIQIWDNDKF SLDDYLGFLE LDLHRTIIPA KTSEKCSLDM IPDLKAMDPL 1920
KAKTASLFEQ RSMKGWWPCY ADKDGTRVMA GKVEMTLEVL NEREADERPA GKGRSEPNMN 1980
PKLDPPNRPE TSFLWFTNPC KTMRFIVWRR FKWVIIGLLL LLILLLFVAV LLYSLPNYLS 2040
MKIVRPNA 2048 |
Gene Ontology | GO:0005901; C:caveola; IDA:UniProtKB. GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. GO:0070062; C:extracellular vesicular exosome; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell. GO:0005543; F:phospholipid binding; IMP:UniProtKB. GO:0034605; P:cellular response to heat; IDA:MGI. GO:0001778; P:plasma membrane repair; IMP:UniProtKB. GO:0030947; P:regulation of vascular endothelial growth factor receptor signaling pathway; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |