CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010045
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 UvrABC system protein A 
Protein Synonyms/Alias
 UvrA protein; Excinuclease ABC subunit A 
Gene Name
 uvrA 
Gene Synonyms/Alias
 MPN_619; MP223 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
945YTAQYLAKILK****acetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity). 
Sequence Annotation
 DOMAIN 5 601 ABC transporter 1.
 DOMAIN 603 943 ABC transporter 2.
 NP_BIND 38 45 ATP 1 (Potential).
 ZN_FING 259 286 C4-type.
 NP_BIND 647 654 ATP 2 (Potential).
 ZN_FING 746 772 C4-type.  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; SOS response; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 948 AA 
Protein Sequence
MKPELKTNDF IRVKGARENN LKNVNIDIPK NQFVVITGLS GSGKSSLAFN TIYAEGRRRY 60
LESLSSYARQ FLGNSDKPDV DSIEGLSPAI SIDQKTTSHN PRSTVGTVTE IYDYLRLLWA 120
RIGIPFCPNG HGAIQTQTVN QIANQIFNLP VKSRIQILAP TIKNQRGTFA NEFAKYQQLG 180
FLRVWVDGQV YTLDEEIKLD KNTKHNLSVV VDRIVINQDK QTLGRIVDAI EGVIKLTEGR 240
IEVLLEDGKI LSFNKNHGCD QCGFSISELE PRLFSFNSPL GSCEYCKGLG FSYEPDVEKI 300
IPNPLLSINE GGIDIFKNIV HGTSLDWQRF LSLINHYQIP LDQPLGQMDT DLVRMILEGS 360
DEPIEIKTVS NSGAKNVRFE HYEGVAHLIK RRHLETSSQA SREWYSAYMS EITCKKCQGK 420
KLTTNSLSVK LGGLDIISFT ELSIDKAIEF LLQIELNQEQ KKIGELALKE IINRLSFLKN 480
VGLEYLNLAR RASTLSGGEA QRIRLATQIG SQLTGVLYVL DEPSIGLHQK DNDRLINTMM 540
VMRDLGNTLL VVEHDSETML AADYLIDIGP KAGNQGGEVV AAGTPLEVME NPDSLTGQYL 600
SGKKQIEVPK TRHAGNGRTL TLKGAKGNNL KNINVTIPLN KLVLVTGVSG SGKSTLINQT 660
LVPILERLVN YKNVKPAPYK EIIGVNHIDK VVVVSQDPIG RTPRSNPATY VSVFDDIREL 720
FANTKEAKAR GYTNSRFSFN VAGGRCDKCF GDGVIRIEMH FLPDVYVTCE MCDGKKYNPQ 780
TLEVKYLGKS IFDVLQMSCQ EAYDFFKAIP NIARKLKLLC DVGLEYLQLG LNVTFLSGGE 840
AQRIKLAKFL QKKATGKTLY VLDEPSTGLH IEDINKLLTV IQRIIKNGDS VIIIEHNLDI 900
IKMADYIIDL GPEGGEKGGQ IIAQGTPEQL LNQVDKSYTA QYLAKILK 948 
Gene Ontology
 GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:HAMAP.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0009380; C:excinuclease repair complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:HAMAP.
 GO:0009381; F:excinuclease ABC activity; IEA:HAMAP.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0006289; P:nucleotide-excision repair; IEA:HAMAP.
 GO:0009432; P:SOS response; IEA:HAMAP.
 GO:0006810; P:transport; IEA:HAMAP. 
Interpro
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR013815; ATP_grasp_subdomain_1.
 IPR027417; P-loop_NTPase.
 IPR004602; UvrA. 
Pfam
 PF00005; ABC_tran 
SMART
  
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS