| Tag | Content |
|---|
| CPLM ID | CPLM-011890 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Plasma membrane-associated coenzyme Q6 reductase PGA3 |
Protein Synonyms/Alias | Processing of GAS1 and ALP protein 3 |
Gene Name | PGA3 |
Gene Synonyms/Alias | NQR1; YML125C; YM4987.10C; YM7056.01C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 164 | SGDTVDFKGPIGTLN | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | NADH-dependent cytochrome b5 reductase that reduces coenzyme Q6 at the plasma membrane and mediates lifespan extension by calorie restriction by shifting fermentative to respiratory metabolism, probably through modulating the NAD(+)/NADH ratio. |
Sequence Annotation | DOMAIN 70 173 FAD-binding FR-type.
NP_BIND 153 168 FAD (By similarity).
NP_BIND 179 211 FAD (By similarity). |
Keyword | Cell membrane; Complete proteome; Endoplasmic reticulum; FAD; Flavoprotein; Membrane; NAD; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 312 AA |
Protein Sequence | MSKEDIEGTN ILDEPVHGIY IPAALFVVGV AITTYMSGEL KILWSLPILF MIIFVRAYSA 60
YKRRRSLYPD RWTSLELEDQ TIISKNTALY RFKLKTRLES LDIPAGHHVA VRVPIDGKQE 120
VRYYNPISSK LESGYLDLVV KAYVDGKVSK YFAGLNSGDT VDFKGPIGTL NYEPNSSKHL 180
GIVAGGSGIT PVLQILNEII TVPEDLTKVS LLYANETEND ILLKDELDEM AEKYPHFQVH 240
YVVHYPSDRW TGDVGYITKD QMNRYLPEYS EDNRLLICGP DGMNNLALQY AKELGWKVNS 300
TRSSGDDQVF VF 312 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IDA:SGD. GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IDA:SGD. GO:0004128; F:cytochrome-b5 reductase activity, acting on NAD(P)H; IMP:SGD. GO:0001300; P:chronological cell aging; IMP:SGD. GO:0015031; P:protein transport; IMP:SGD. GO:0001302; P:replicative cell aging; IMP:SGD. |
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