UniProt Accession

 UPP1_HUMAN; Q16831; D3DVM4; Q15362 

Genbank Protein ID

 X90858; X90858; BT006699; CH471128; CH471128; BC001405; BC007348; BC053592 

Genbank Nucleotide ID

 CAA62369.1; CAA62370.1; AAP35345.1; EAW60994.1; EAW60995.1; AAH01405.1; AAH07348.1; AAH53592.1 

Protein Name

 Uridine phosphorylase 1 

Protein Synonyms/Alias

 UPase 1; UrdPase 1 

Gene Name

 UPP1 

Gene Synonyms/Alias

 UP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
232	CSYTEKDKQAYLEAA	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. 

Sequence Annotation

 BINDING 217 217 Substrate.
 BINDING 219 219 Substrate.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Glycosyltransferase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 310 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004850; F:uridine phosphorylase activity; TAS:ProtInc.
 GO:0042149; P:cellular response to glucose starvation; IEA:Compara.
 GO:0009166; P:nucleotide catabolic process; IEA:InterPro.
 GO:0006206; P:pyrimidine nucleobase metabolic process; TAS:Reactome.
 GO:0046135; P:pyrimidine nucleoside catabolic process; TAS:Reactome.
 GO:0043097; P:pyrimidine nucleoside salvage; TAS:Reactome.
 GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
 GO:0046108; P:uridine metabolic process; IEA:Compara. 

Interpro

 IPR018017; Nucleoside_phosphorylase.
 IPR018016; Nucleoside_phosphorylase_CS.
 IPR000845; Nucleoside_phosphorylase_d.
 IPR010059; Uridine_phosphorylase_euk. 

Pfam

 PF01048; PNP_UDP_1 

SMART

  

PROSITE

 PS01232; PNP_UDP_1 

PRINTS