UniProt Accession

 GNA14_HUMAN; O95837 

Genbank Protein ID

 AF105201; AF493903; BC027886 

Genbank Nucleotide ID

 AAD17944.1; AAM12617.1; AAH27886.1 

Protein Name

 Guanine nucleotide-binding protein subunit alpha-14 

Protein Synonyms/Alias

 G alpha-14; G-protein subunit alpha-14 

Gene Name

 GNA14 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
48	LGTGESGKSTFIKQM	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. 

Sequence Annotation

 NP_BIND 42 49 GTP (By similarity).
 NP_BIND 176 182 GTP (By similarity).
 NP_BIND 201 205 GTP (By similarity).
 NP_BIND 270 273 GTP (By similarity).
 METAL 49 49 Magnesium (By similarity).
 METAL 182 182 Magnesium (By similarity).
 BINDING 327 327 GTP; via amide nitrogen (By similarity).
 MOD_RES 179 179 ADP-ribosylarginine; by cholera toxin (By  

Keyword

 ADP-ribosylation; Complete proteome; GTP-binding; Magnesium; Metal-binding; Nucleotide-binding; Reference proteome; Transducer. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 355 AA 

Protein Sequence

Gene Ontology

 GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
 GO:0001664; F:G-protein coupled receptor binding; IBA:RefGenome.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; IBA:RefGenome.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IBA:RefGenome.
 GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IBA:RefGenome.
 GO:0030168; P:platelet activation; TAS:Reactome. 

Interpro

 IPR000654; Gprotein_alpha_Q.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00503; G-alpha 

SMART

 SM00275; G_alpha 

PROSITE

  

PRINTS

 PR00318; GPROTEINA.
 PR00442; GPROTEINAQ.