UniProt Accession

 B7Z6M4_HUMAN; B7Z6M4 

Genbank Protein ID

 AC002094; AK300584 

Genbank Nucleotide ID

 BAH13310.1 

Protein Name

 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 

Protein Synonyms/Alias

 cDNA FLJ50737, highly similar to BTB/POZ domain-containing protein TNFAIP1 

Gene Name

 TNFAIP1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
51	RLIESSTKPVVKLLY	ubiquitination	[1]
64	LYNRSNNKYSYTSNS	ubiquitination	[2]
130	SIVYATEKKQTKVEF	ubiquitination	[3]
131	IVYATEKKQTKVEFP	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 212 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0006260; P:DNA replication; IEA:Compara.
 GO:0009790; P:embryo development; IEA:Compara.
 GO:0045740; P:positive regulation of DNA replication; IEA:Compara. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS