CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029245
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nipped-A, isoform D 
Protein Synonyms/Alias
  
Gene Name
 Nipped-A 
Gene Synonyms/Alias
 CG33554; Dmel_CG33554 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
2787LMKIALAKTEQCYLKacetylation[1]
2794KTEQCYLKHYGFKINacetylation[1]
3357TNDFDFSKPGAMKLHacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3790 AA 
Protein Sequence
MSVIENVPVN TFRNYLNILN DSSSKDELKL KATQELSEHF EMIMQSPAYP SFLDNSLKIF 60
MRILQDGEPQ FIQENTMQHI RKLILEMIHR LPITESLRQH VKTIITMMLK ILKTDNEENV 120
LVCLRIIIEL HKHFRPSFNS EIQLFLGFVK EIYTNLPNHL TSIFETSNDV WVTDLKDLNL 180
EVLLSESYSV RTIHVEKALD SNSQQQIYNL LPRGILSLKV LQELPIIVVL MYQIYKNAVH 240
QEVSEFIPLI LTTINLQPTV TRRNSPQKEI YVEFMGAQIK TLSFLAYIVR IFQEVVIASS 300
LSVTSGMLNL MKNCPKEAAH LRKELLIAAR HIFATDLRQK FIPSIEQLFD EDLLIGKGVT 360
LDSIRPLAYS TLADLAHHVR QSLNIDVLIK AVNLFSKNVH DESLAVGIQT MSCKLLLNLV 420
DCLRHHSETE PQRSKALLSK LLKVFVKKFE TIAKIQLPLI IQKCKGHAFS GALVNSSGNA 480
SLSHINAPDL KDDISNIQVS ASGSQWIYSV NVAEFRSLVK TLVGGVKTIT WGFFNSKFQL 540
TDTKLANHEK IFGPEIVCSY IDLVYYAMEA LDIYTINVNP NQQRTSGLIS RSKEEKEVLE 600
HFSGIFLMMH SQNFQEIFST TINFLVERIY KNQSLQVIAN SFLANPTTSP LFATVLVEYL 660
LNKMEEMGSN LERSNLYLRL FKLVFGSVSL FPVENEQMLR PHLHKIVNRS MELALISEEP 720
YNYFLLLRAL FRSIGGGSHD LLYQEFLPLL PNLLEGLNRL QSGFHKQHMR DLFVELCLTV 780
PVRLSSLLPY LPMLMDPLVS ALNGSPTLIS QGLRTLELCV DNLQPDFLYD HIQPVRAALM 840
QALWKTLRNQ DNAALVAFRV LGKFGGGNRK MMVEPQALSY IINDKPTISI VTYFQEYETP 900
IDFPVDEAIK SAFRALGSNS TDQFYRRQSW EVIRCFLAAF ISLDDEKHML LKLFTHVDFV 960
ENKIMNWSTF QHKAGNETVR ETHQTALIGM LVASATKDLR DSVCPVMAAV VRHYTMVAIA 1020
QQAGPFPQKG YQATHGIDPM ILIDALASCM GHEEKELCKP GIACMGIILD TATNIMGNKD 1080
RACKLPIIQY LAEKMVSLCY DRPWYSKVGG CQAIQFLCKH MSLRALFQNL FNFLKAFMFV 1140
LMDLEGDVSN GAIEITKSYM KSMLEICLTP INECYKNIDL KDLQAKATYE VIHELVRHIT 1200
SPNTIVREES MVLLKHIGTI QSKTVSEVMD PHKDVLADII PPKKHLLRHQ PANAQIGLMD 1260
GNTFCTTLEP RLFTIDLTNT YHKLFFHELL TLSEAEDATL AKLDCYKNVP NLIPLRTSAL 1320
RALAACHYIS DIGYKEKIIN IIFKVMESDK SELQTTAFHC MKHFITGVTL EKEKVQSAMR 1380
PLLLKLGDHR NLSIPAIKRL SYFTQIFPQM FNEKLSEQIL QHCSKIMEIF VSEYKSTSPN 1440
VNFFASSKGG EYEQKIVILI EMFFYISASV KYIEKLCQLV LKTEKNLMIE ASSPYREALI 1500
KFLQRFPTET VDLFLTESLM IDPQWNRLFI YLLKHETGVS FRAVIKSSRY NNLIHYLNTH 1560
TEFPEALKYE IQHQAVLIIF TLMESDDQWI PTRQDIVDAL KNCWQNYLST LSSEDVLCDL 1620
WHLIGKILLH YFSNNTNDIE LLFQLLRALC FRFIPDVYFL RDFLQHTVAQ SFTVNWKRNA 1680
FFYFVENFNN SFLSEELKAK IITAVIIPCF AVSFDKGEGN KLIGAPPTPY QEDEKNIVSV 1740
FINKVFDPDK QYDDAVRIAL LQLACLLVER ASQHIHDGDA NNKRQGNKLR RLMTFAWPCL 1800
LSKSSVDPTA RYHGHLLLSH IIARLAIHKK IVLQVFHSLL KGHALEARSI VKQALDVLTP 1860
AMPLRMEDGN TMLTHWTKKI IVEEGHAMQQ LFHILQLIIR HYKVYFPVRH QLVQHLINYM 1920
QRLGFPPTAS IEHKKLAVDL AEVIIKWELH RIKDDRETKT DGTEEELIQE SSVKRSGIDL 1980
VETRKKSFDI IRETTVQGMG SHTKPDDILR SIDKSYCDTV LNFLIRLACQ VNDPQAPILS 2040
PGESLSRRCV MLLKMAMRPE IWPQPFDIKL NWLDKVLATV ETPHHNLNNI CTGIDFLTFL 2100
TTILSPDQLV SIIRPVQRGL SLCIIHQNTR IVRLMHMFLT RIMAIFPPDT QHKHEDLDLL 2160
YTAVSKMIAE NLTSYEKSPQ PNASSLFGTL MILKACTTNN ASYIDRILVQ FIRVLNHLTR 2220
DHINTIGGNT VISQSPDSNA LPLELLVLSL ELIKNRIFVM SVEIRKLFIG TILVSLIEKS 2280
TEVKIIKCII KMLDEWIKTK EPNVMTQVPS IREKSALLVK LMQNVEKKFT DEIELNIQFL 2340
EIINFIYRDE ILKQTELTNK LEGAFLNGLR FQNPNVRSKF FEILDSSMRR RLHDRLLYII 2400
CSQAWDTIGS HYWIKQCIEL LILTANTMMQ IQCSNEQFKI PSITSVIPVN SSETQENSFV 2460
SFLSSHSESF DIIQTVDDKD DVYDIDLNAD RKEDCQQILP NRRVTLVELV YKQAEFLEAN 2520
RNIRTDQMLV ATSQLCHIDT QLAQSVWLSM FPRIWSIFTE DQRCNITKEL IPFLSSGTNV 2580
NQKDCHPSTL NTFVESLTKC APPIYIPPNL LAYLGKSHNL WHRAILVLED MAVNQSMQSK 2640
DIDGGENQFS DLDVQQSNNI FDSLSKMYSS MHEEDLWAGL WLKFAHYPET NIAVSYEQMG 2700
FFEEAQGAYD LAMTKFKQDL SNGVVNTYVN SELLLWENHW MRCAKELNQW DILLDYAQTN 2760
KDKNMFLILE SSWRVPDWNL MKIALAKTEQ CYLKHYGFKI NLYKGYLSIL HQEERQTGNI 2820
ERYVEIASSL CIREWRRLPN IVSHIHLPYL QASQQIMELH EASQIHQGLA QSRNNSLHDM 2880
KAIVKTWRNR LPIISDDLSH WSDIFTWRQH HYQIITQHLE QQSDQGSTML GVHASAQAII 2940
SFGKIARKHN LTGVCQETLS RIYTIPSVPI VDCFQKIRQQ VKCYLQMPST SGKNEINEAL 3000
EVIESTNLKY FTGEMNAEFY ALKGLLLAQI GRSEEAGKSF SVAAQLHDGL TKAWAMWGDY 3060
MEQIFLKERK ITLAVDALIC YLQASRNQIE SKTRKYIAKV LWFLSYDNNT KILISTLEKH 3120
VAGIPPSYWL PWIPQLLCCL EQFEGDVILN LLSQIGRLYP QAVYFPIRTL YLTLKIEQRE 3180
KHKTAEQAVK SSCSNIDGTT LSFGRGASHG NIPSINPIKA TPPMWRCSKV MQLQREVHPT 3240
ILSSLEGIVD QMVWFRESWT EEVLRQLRQG LIKCYAIAFE KRDTVQHSTI TPHTLHFVKK 3300
LGSTFGIGIE NVPGSVTSSI SNSAASESLA RRAQVTFQDP VFQKMKEQFT NDFDFSKPGA 3360
MKLHNLISKL KTWIKVLETK VKKLPTSFLI EDKCRFLSNF SQKTAEVELP GELLIPLSSH 3420
YYVRIARFMP RVEIVQKNNT AARRLYIRGT NGKIYPYLVV LDSGLGDARR EERVLQLKRM 3480
LNYYLEKQKE TSRRFLNITV PRVVPISPQM RLAEDNPNSI SLLKIFKKCC QSMQVDYDMP 3540
IVKYYDRLSE VQARGTPTTH TLLREIFSEI QWTMVPKTLL KHWALKTFLA ATDFWHFRKM 3600
LTLQLALAFL CEHALNLTRL NADMMYLHQD SGLMNISYFK FDVNDDKCQL NQHRPVPFRL 3660
TPNVGEFITH FGITGPLSAA IVATARCFIQ PNYKLSSILQ TILRDEIIAL QKKGFRECKL 3720
IEGSEDRYSD GNCMEHSVNI VNSAVDIIMT RFNKISYFDS IENKKISVLV QSATNIDNLC 3780
RMDPAWHPWL 3790 
Gene Ontology
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR003152; FATC.
 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR003151; PIK-rel_kinase_FAT.
 IPR014009; PIK_FAT. 
Pfam
 PF02259; FAT
 PF02260; FATC
 PF00454; PI3_PI4_kinase 
SMART
 SM00146; PI3Kc 
PROSITE
 PS51189; FAT
 PS51190; FATC
 PS50290; PI3_4_KINASE_3 
PRINTS