CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021750
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Syntenin-1 
Protein Synonyms/Alias
 Syndecan-binding protein 1 
Gene Name
 Sdcbp 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
11YPSLEDLKVDKVIQAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. 
Sequence Annotation
 DOMAIN 116 195 PDZ 1.
 DOMAIN 200 274 PDZ 2.
 MOD_RES 2 2 N-acetylserine (By similarity).  
Keyword
 Acetylation; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 300 AA 
Protein Sequence
MSLYPSLEDL KVDKVIQAQT ASSANPASQA FFLNVVDSAA FPPGGNLYPK LYPELSQYMG 60
LSLSEAEICE NMPVVSGAPT QGQLVARPSS VNYMVAPVTG NDAGIRRAEI KQGIREVILC 120
KDQDGKIGLR LKSVDNGIFV QLVQANSPAS LVGLRFGDQV LQINGENCAG WSSDKAHKVL 180
KQAFGEKITM TIRDRPFERT VTMHKDSSGH VGFIFKSGKI TSIVKDSSAA RNGLLTDHHI 240
CEINGQNVIG LKDAQIADIL STAGTVVTIT IMPAFIFEHI IKRMAPSIMK SLMDHTIPEV 300 
Gene Ontology
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0005895; C:interleukin-5 receptor complex; ISS:UniProtKB.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005137; F:interleukin-5 receptor binding; ISS:UniProtKB.
 GO:0042043; F:neurexin family protein binding; NAS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0042327; P:positive regulation of phosphorylation; IEA:Compara.
 GO:0007265; P:Ras protein signal transduction; IEA:Compara. 
Interpro
 IPR001478; PDZ. 
Pfam
 PF00595; PDZ 
SMART
 SM00228; PDZ 
PROSITE
 PS50106; PDZ 
PRINTS