UniProt Accession

 RL40_PIG; P63053; P02248; P02249; P02250; P62974; Q29120; Q29203; Q29252; Q91887; Q91888; Q95260 

Genbank Protein ID

 U72496 

Genbank Nucleotide ID

 AAB52914.1 

Protein Name

 Ubiquitin-60S ribosomal protein L40 

Protein Synonyms/Alias

 CEP52; Ubiquitin A-52 residue ribosomal protein fusion product 1; Ubiquitin; 60S ribosomal protein L40 

Gene Name

 UBA52 

Gene Synonyms/Alias

 UBCEP2 

Created Date

 July 27, 2013 

Organism

 Sus scrofa (Pig) 

NCBI Taxa ID

 9823 

Lysine Modification

Position	Peptide	Type	References
6	**MQIFVKTLTGKTI	acetylation	[1]
11	FVKTLTGKTITLEVE	acetylation	[1]
27	SDTIENVKAKIQDKE	acetylation	[1]
29	TIENVKAKIQDKEGI	acetylation	[1]
33	VKAKIQDKEGIPPDQ	acetylation	[1]
48	QRLIFAGKQLEDGRT	acetylation	[1]
63	LSDYNIQKESTLHLV	acetylation	[1]

Reference

 [1] N-epsilon-acetylation of porcine mature erythrocytes ubiquitin.
 Zhu DX, Xu LX, Zhu NZ, Briand G, Han KK.
 Int J Biochem. 1985;17(6):719-21. [PMID: 2993057] 

Functional Description

 Ubiquitin: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). 

Sequence Annotation

 DOMAIN 1 76 Ubiquitin-like.
 BINDING 54 54 Activating enzyme.
 BINDING 72 72 Activating enzyme.
 MOD_RES 6 6 N6-acetyllysine; alternate.
 MOD_RES 48 48 N6-acetyllysine; alternate.
 MOD_RES 57 57 Phosphoserine (By similarity).
 MOD_RES 65 65 Phosphoserine.
 MOD_RES 88 88 N6-acetyllysine (By similarity).
 MOD_RES 98 98 N6,N6,N6-trimethyllysine (By similarity).
 CROSSLNK 6 6 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 11 11 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 27 27 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 29 29 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 33 33 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 48 48 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 63 63 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 76 76 Glycyl lysine isopeptide (Gly-Lys)  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Isopeptide bond; Methylation; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 128 AA 

Protein Sequence

Gene Ontology

 GO:0022625; C:cytosolic large ribosomal subunit; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0006412; P:translation; IEA:InterPro. 

Interpro

 IPR001975; Ribosomal_L40e.
 IPR000626; Ubiquitin.
 IPR019954; Ubiquitin_CS.
 IPR019956; Ubiquitin_subgr.
 IPR019955; Ubiquitin_supergroup. 

Pfam

 PF01020; Ribosomal_L40e
 PF00240; ubiquitin 

SMART

 SM00213; UBQ 

PROSITE

 PS00299; UBIQUITIN_1
 PS50053; UBIQUITIN_2 

PRINTS

 PR00348; UBIQUITIN.