UniProt Accession

 ERV2_YEAST; Q12284; D6W448 

Genbank Protein ID

 Z71255; Z68111; BK006949 

Genbank Nucleotide ID

 CAA94987.1; CAA92143.1; DAA11464.1 

Protein Name

 FAD-linked sulfhydryl oxidase ERV2 

Protein Synonyms/Alias

  

Gene Name

 ERV2 

Gene Synonyms/Alias

 YPR037C; YP3085.03C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
42	TPGLIKAKSGIDEVQ	ubiquitination	[1]
55	VQGAAAEKNDARLKE	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation in the endoplasmic reticulum lumen in parallel to ERO1. 

Sequence Annotation

 DOMAIN 72 174 ERV/ALR sulfhydryl oxidase.
 REGION 78 86 FAD-binding.
 REGION 153 174 FAD-binding.
 DISULFID 121 124 Redox-active (Potential).
 DISULFID 150 167
 DISULFID 176 178  

Keyword

 3D-structure; Complete proteome; Disulfide bond; Endoplasmic reticulum; FAD; Flavoprotein; Membrane; Oxidoreductase; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 196 AA 

Protein Sequence

Gene Ontology

 GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:SGD.
 GO:0003756; F:protein disulfide isomerase activity; IGI:SGD.
 GO:0016972; F:thiol oxidase activity; IDA:SGD. 

Interpro

 IPR017905; ERV/ALR_sulphydryl_oxidase.
 IPR006863; Evr1_Alr. 

Pfam

 PF04777; Evr1_Alr 

SMART

  

PROSITE

 PS51324; ERV_ALR 

PRINTS