UniProt Accession

 IF5A2_HUMAN; Q9GZV4; B2R4V5 

Genbank Protein ID

 AF262027; AF293387; AF293386; AY205258; AY205259; AY205260; AY205261; AK311962; CH471052; BC036072 

Genbank Nucleotide ID

 AAF98810.1; AAG23176.1; AAG23176.1; AAO18676.1; AAO18677.1; AAO18678.1; AAO18679.1; BAG34902.1; EAW78501.1; AAH36072.1 

Protein Name

 Eukaryotic translation initiation factor 5A-2 

Protein Synonyms/Alias

 eIF-5A-2; eIF-5A2; Eukaryotic initiation factor 5A isoform 2 

Gene Name

 EIF5A2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
27	MQCSALRKNGFVVLK	ubiquitination	[1]
34	KNGFVVLKGRPCKIV	ubiquitination	[1]
39	VLKGRPCKIVEMSTS	ubiquitination	[1]
67	GIDIFTGKKYEDICP	ubiquitination	[1]
68	IDIFTGKKYEDICPS	ubiquitination	[1]
85	NMDVPNIKRNDYQLI	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). 

Sequence Annotation

 MOD_RES 2 2 Blocked amino end (Ala) (By similarity).
 MOD_RES 50 50 Hypusine.  

Keyword

 Complete proteome; Cytoplasm; Elongation factor; Endoplasmic reticulum; Hypusine; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Polymorphism; Protein biosynthesis; Protein transport; Reference proteome; RNA-binding; Translocation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 153 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
 GO:0043022; F:ribosome binding; IEA:InterPro.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0008612; P:peptidyl-lysine modification to hypusine; TAS:Reactome.
 GO:0010509; P:polyamine homeostasis; NAS:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; IGI:UniProtKB.
 GO:0045901; P:positive regulation of translational elongation; IEA:InterPro.
 GO:0045905; P:positive regulation of translational termination; IEA:InterPro.
 GO:0043687; P:post-translational protein modification; TAS:Reactome.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007283; P:spermatogenesis; NAS:UniProtKB.
 GO:0006452; P:translational frameshifting; IEA:InterPro. 

Interpro

 IPR005824; KOW.
 IPR012340; NA-bd_OB-fold.
 IPR014722; Rib_L2_dom2.
 IPR019769; Trans_elong_IF5A_hypusine_site.
 IPR001884; Transl_elong_IF5A.
 IPR020189; Transl_elong_IF5A_C.
 IPR008991; Translation_prot_SH3-like. 

Pfam

 PF01287; eIF-5a
 PF00467; KOW 

SMART

  

PROSITE

 PS00302; IF5A_HYPUSINE 

PRINTS