| Tag | Content |
|---|
| CPLM ID | CPLM-013856 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier family 12 member 7 |
Protein Synonyms/Alias | Electroneutral potassium-chloride cotransporter 4; K-Cl cotransporter 4 |
Gene Name | Slc12a7 |
Gene Synonyms/Alias | Kcc4 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 114 | DSRRREIKAPRMGTF | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). |
Sequence Annotation | MOD_RES 50 50 Phosphoserine (By similarity).
MOD_RES 62 62 Phosphoserine (By similarity).
MOD_RES 926 926 Phosphothreonine (By similarity).
MOD_RES 980 980 Phosphothreonine (By similarity).
CARBOHYD 312 312 N-linked (GlcNAc...) (Potential).
CARBOHYD 331 331 N-linked (GlcNAc...) (Potential).
CARBOHYD 344 344 N-linked (GlcNAc...) (Potential).
CARBOHYD 360 360 N-linked (GlcNAc...) (Potential). |
Keyword | Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Potassium; Potassium transport; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1083 AA |
Protein Sequence | MPTNFTVVPV EARADGAGDE AAERTEEPGS PESADPACPT PGDGNPRENS PFINNVEVER 60
ESYFEGKNMA LFEEEMDSNP MVSSLLNKLA NYTNLSQGVV EHEEDEDSRR REIKAPRMGT 120
FIGVYLPCLQ NILGVILFLR LTWIVGAAGV LESFLIVAMC CTCTMLTAIS MSAIATNGVV 180
PAGGSYYMIS RSLGPEFGGA VGLCFYLGTT FAGAMYILGT IEIFLTYISP SAAIFQAETA 240
DGEAAALLNN MRVYGSCALA LMAVVVFVGV KYVNKLALVF LACVVLSILA IYAGVIKTAF 300
APPDIPVCLL GNRTLANRNF DTCAKMQVVS NGTVTTALWR LFCNGSSLGA SCDEYFVQNN 360
VTEIQGIPGV ASGVFLDNLW STYSDKGAFV EKKGVSSVPV SEESRPGGLP YVLTDIMTYF 420
TMLVGIYFPS VTGIMAGSNR SGDLKDAQKS IPTGTILAIV TTSFIYLSCI VLFGACIEGV 480
VLRDKFGEAL QGNLVIGMLA WPSPWVIVIG SFFSTCGAGL QSLTGAPRLL QAIARDGIIP 540
FLQVFGHGKA NGEPTWALLL TALICETGIL IASLDSVAPI LSMFFLMCYM FVNLACAVQT 600
LLRTPNWRPR FKFYHWTLSF LGMSLCLALM FICSWYYALF AMLIAGCIYK YIEYRGAEKE 660
WGDGIRGLSL NAARYALLRV EHGPPHTKNW RPQVLVMLNL DSEQCVKHPR LLSFTSQLKA 720
GKGLTIVGSV LEGTYLDKHV EAQRAEENIR SLMSAEKMKG FCQLVVSSNL RDGASHLIQS 780
AGLGGMKHNT VLMAWPEAWK QADNPFSWKN FVDTVRDTTA AHQALLVAKN IDLFPQNQER 840
FSDGNIDVWW IVHDGGMLML LPFLLRQHKV WRKCRMRIFT VAQVDDNSIQ MKKDLQMFLY 900
HLRISAEVEV VEMVENDISA FTYEKTLMME QRSQMLKQMQ LSKNEREREA QLIHDRNTAS 960
HTVATARTEA PPTPDKVQMT WTKEKLIAEK HRNKDTGTSG FKDLFSLKPD QSNVRRMHTA 1020
VKLNGVVLNK SQDAQLVLLN MPGPPKSRQG DENYMEFLEV LTEGLNRVLL VRGGGREVIT 1080
IYS 1083 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0015379; F:potassium:chloride symporter activity; TAS:RGD. GO:0006884; P:cell volume homeostasis; IMP:RGD. GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |