CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037470
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tubulin polyglutamylase TTLL4 
Protein Synonyms/Alias
  
Gene Name
 TTLL4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
523MQSRFGKKEFSFFPQubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 973 AA 
Protein Sequence
MVFSMAQPMA SSSTEPYLCL AAAGENPSGK SLASAISGKI PSPLSSSYKP MLNNNSFMWP 60
NSTPVPLLQT TQGLKPVSPP KIQPVSWHHS GGTGDCAPQP VDHKVPKSIG TVPADASAHI 120
ALSTASSHDT STTSVASSWY NRNNLAMRAE PLSCALDDSS DSQDPTKEIR FTEAVRKLTA 180
RGFEKMPRQG CQLEQSSFLN PSFQWNVLNR SRRWKPPAVN QQFPQEDAGS VRRVLPGASD 240
TLGLDNTVFC TKRISIHLLA SHASGLNHNP ACESVIDSSA FGEGKAPGPP FPQTLGIANV 300
ATRLSSIQLG QSEKERPEEA RELDSSDRDI SSATDLQPDQ AETEDTEEEL VDGLEDCCSR 360
DENEEEEGDS ECSSLSAVSP SESVAMISRS CMEILTKPLS NHEKVVRPAL IYSLFPNVPP 420
TIYFGTRDER VEKLPWEQRK LLRWKMSTVT PNIVKQTIGR SHFKISKRND DWLGCWGHHM 480
KSPSFRSIRE HQKLNHFPGS FQIGRKDRLW RNLSRMQSRF GKKEFSFFPQ SFILPQDAKL 540
LRKAWESSSR QKWIVKPPAS ARGIGIQVIH KWSQLPKRRP LLVQRYLHKP YLISGSKFDL 600
RIYVYVTSYD PLRIYLFSDG LVRFASCKYS PSMKSLGNKF MHLTNYSVNK KNAEYQANAD 660
EMACQGHKWA LKALWNYLSQ KGVNSDAIWE KIKDVVVKTI ISSEPYVTSL LKMYVRRPYS 720
CHELFGFDIM LDENLKPWVL EVNISPSLHS SSPLDISIKG QMIRDLLNLA GFVLPNAEDI 780
ISSPSSCSSS TTSLPTSPGD KCRMAPEHVT AQKMKKAYYL TQKIPDQDFY ASVLDVLTPD 840
DVRILVEMED EFSRRGQFER IFPSHISSRY LRFFEQPRYF NILTTQWEQK YHGNKLKGVD 900
LLRSWCYKGF HMGVVSDSAP VWSLPTSLLT ISKDDVILNA FSKSETSKLG NPVPQRTVRT 960
PAKSPAFLPR RYL 973 
Gene Ontology
 GO:0004835; F:tubulin-tyrosine ligase activity; IEA:InterPro.
 GO:0006464; P:cellular protein modification process; IEA:InterPro. 
Interpro
 IPR004344; Tub_tyr_ligase. 
Pfam
 PF03133; TTL 
SMART
  
PROSITE
 PS51221; TTL 
PRINTS