UniProt Accession

 FIS1_MOUSE; Q9CQ92 

Genbank Protein ID

 AK004479; AK004917; AK008078; AK008323; AK008916; BC010783 

Genbank Nucleotide ID

 BAB23324.1; BAB23668.1; BAB25445.1; BAB25601.1; BAB25966.1; AAH10783.1 

Protein Name

 Mitochondrial fission 1 protein 

Protein Synonyms/Alias

 FIS1 homolog; Tetratricopeptide repeat protein 11; TPR repeat protein 11 

Gene Name

 Fis1 

Gene Synonyms/Alias

 Ttc11 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
20	DLKNFERKFQSEQAA	ubiquitination	[1]
46	AWCLVRSKYNEDIRR	acetylation	[2]
64	LLEELLPKGSKEEQR	ubiquitination	[1]
108	EPQNNQAKELERLID	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission (By similarity). 

Sequence Annotation

 REPEAT 71 104 TPR.
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 3D-structure; Acetylation; Apoptosis; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion outer membrane; Peroxisome; Reference proteome; TPR repeat; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 152 AA 

Protein Sequence

Gene Ontology

 GO:0031307; C:integral to mitochondrial outer membrane; ISS:UniProtKB.
 GO:0005779; C:integral to peroxisomal membrane; ISS:UniProtKB.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Compara.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:Compara.
 GO:0051561; P:elevation of mitochondrial calcium ion concentration; IEA:Compara.
 GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; ISS:UniProtKB.
 GO:0000422; P:mitochondrion degradation; IEA:Compara.
 GO:0070584; P:mitochondrion morphogenesis; ISO:MGI.
 GO:0016559; P:peroxisome fission; ISS:UniProtKB.
 GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0006626; P:protein targeting to mitochondrion; IEA:Compara.
 GO:0032471; P:reduction of endoplasmic reticulum calcium ion concentration; IEA:Compara.
 GO:0010821; P:regulation of mitochondrion organization; IEA:Compara.
 GO:0001836; P:release of cytochrome c from mitochondria; IEA:Compara. 

Interpro

 IPR016543; Tetratricopeptide_rpt_11_Fis1.
 IPR011990; TPR-like_helical. 

Pfam

  

SMART

  

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS