CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030530
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA excision repair protein ERCC-1 
Protein Synonyms/Alias
 cDNA FLJ34720 fis, clone MESAN2005724, highly similar to DNA EXCISION REPAIR PROTEIN ERCC-1 
Gene Name
 ERCC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
42VRGNPVLKFVRNVPWubiquitination[1]
90GRLQSLGKNFALRVLubiquitination[1, 2, 3]
104LLVQVDVKDPQQALKubiquitination[1]
141GRYLETYKAYEQKPAubiquitination[1]
154PADLLMEKLEQDFVSubiquitination[1]
171TECLTTVKSVNKTDSubiquitination[1, 3]
209CPGLGPQKARRLFDVubiquitination[1, 3]
223VLHEPFLKVP*****ubiquitination[1, 3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 225 AA 
Protein Sequence
MDPGKDKEGV PQPSGPPARK KFVIPLDEDE VPPGVRGNPV LKFVRNVPWE FGDVIPDYVL 60
GQSTCALFLS LRYHNLHPDY IHGRLQSLGK NFALRVLLVQ VDVKDPQQAL KELAKMCILA 120
DCTLILAWSP EEAGRYLETY KAYEQKPADL LMEKLEQDFV SRVTECLTTV KSVNKTDSQT 180
LLTTFGSLEQ LIAASREDLA LCPGLGPQKA RRLFDVLHEP FLKVP 225 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003684; F:damaged DNA binding; IEA:InterPro.
 GO:0004519; F:endonuclease activity; IEA:InterPro.
 GO:0006281; P:DNA repair; IEA:InterPro. 
Interpro
 IPR004579; DNA_repair_Rad10.
 IPR000445; HhH_motif.
 IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
 IPR011335; Restrct_endonuc-II-like.
 IPR010994; RuvA_2-like. 
Pfam
 PF00633; HHH
 PF03834; Rad10 
SMART
 SM00278; HhH1 
PROSITE
  
PRINTS