UniProt Accession

 NECP1_MOUSE; Q9CR95; Q3TH13; Q78JW3; Q8C4P1 

Genbank Protein ID

 AK004805; AK005263; AK081598; AK168500; BC011466; BK000656 

Genbank Nucleotide ID

 BAB23577.2; BAB23915.2; BAC38266.1; BAE40385.1; AAH11466.2; DAA01433.1 

Protein Name

 Adaptin ear-binding coat-associated protein 1 

Protein Synonyms/Alias

 NECAP endocytosis-associated protein 1; NECAP-1 

Gene Name

 Necap1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
59	KGKIAYIKLEDKVSG	ubiquitination	[1]
131	QDHFKWVKQETEISK	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Involved in endocytosis (By similarity). 

Sequence Annotation

 MOTIF 252 255 WXXF motif 1.
 MOTIF 272 275 WXXF motif 2.  

Keyword

 3D-structure; Cell membrane; Complete proteome; Cytoplasmic vesicle; Endocytosis; Membrane; Protein transport; Reference proteome; Repeat; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 275 AA 

Protein Sequence

Gene Ontology

 GO:0030125; C:clathrin vesicle coat; IDA:UniProtKB.
 GO:0005905; C:coated pit; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0006897; P:endocytosis; IMP:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR012466; NECAP-1.
 IPR011993; PH_like_dom. 

Pfam

 PF07933; DUF1681 

SMART

  

PROSITE

  

PRINTS