UniProt Accession

 RPAB2_YEAST; P20435; D6W4I7 

Genbank Protein ID

 X53288; M33924; U25841; BK006949 

Genbank Nucleotide ID

 CAA37382.1; AAA34989.1; AAB64616.1; DAA11603.1 

Protein Name

 DNA-directed RNA polymerases I, II, and III subunit RPABC2 

Protein Synonyms/Alias

 RNA polymerases I, II, and III subunit ABC2; ABC23; DNA-directed RNA polymerases I, II, and III 23 kDa polypeptide 

Gene Name

 RPO26 

Gene Synonyms/Alias

 RPB6; YPR187W; P9677.8 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
46	ETTDANGKTIVTGGN	acetylation	[1]
46	ETTDANGKTIVTGGN	ubiquitination	[2]
123	DPLRIAMKELAEKKI	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and togther with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity). 

Sequence Annotation

 REGION 111 132 Leucine-zipper.
 MOD_RES 24 24 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; DNA-directed RNA polymerase; Nucleus; Phosphoprotein; Reference proteome; Transcription. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 155 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005736; C:DNA-directed RNA polymerase I complex; IDA:SGD.
 GO:0005665; C:DNA-directed RNA polymerase II, core complex; IDA:SGD.
 GO:0005666; C:DNA-directed RNA polymerase III complex; IDA:SGD.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
 GO:0006360; P:transcription from RNA polymerase I promoter; IDA:SGD.
 GO:0006366; P:transcription from RNA polymerase II promoter; IMP:SGD.
 GO:0042797; P:tRNA transcription from RNA polymerase III promoter; IDA:SGD. 

Interpro

 IPR020708; DNA-dir_RNA_polK_14-18kDa_CS.
 IPR006110; RNA_poly_omega/K/RPABC2.
 IPR006111; RNAP_K/Rpb6.
 IPR012293; RNAP_RPB6_omega. 

Pfam

 PF01192; RNA_pol_Rpb6 

SMART

  

PROSITE

 PS01111; RNA_POL_K_14KD 

PRINTS