CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013978
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protrudin 
Protein Synonyms/Alias
 Zinc finger FYVE domain-containing protein 27 
Gene Name
 ZFYVE27 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
55EIYLEPLKDAGDGVRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation. 
Sequence Annotation
 ZN_FING 344 410 FYVE-type.
 REGION 51 64 Necessary for interaction with RAB11A and
 REGION 286 292 Necessary for interaction with VAPA and
 CARBOHYD 209 209 N-linked (GlcNAc...) (Potential).  
Keyword
 3D-structure; Alternative splicing; Cell membrane; Cell projection; Complete proteome; Disease mutation; Endoplasmic reticulum; Endosome; Glycoprotein; Hereditary spastic paraplegia; Membrane; Metal-binding; Neurodegeneration; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 411 AA 
Protein Sequence
MQTSEREGSG PELSPSVMPE APLESPPFPT KSPAFDLFNL VLSYKRLEIY LEPLKDAGDG 60
VRYLLRWQMP LCSLLTCLGL NVLFLTLNEG AWYSVGALMI SVPALLGYLQ EVCRARLPDS 120
ELMRRKYHSV RQEDLQRGRL SRPEAVAEVK SFLIQLEAFL SRLCCTCEAA YRVLHWENPV 180
VSSQFYGALL GTVCMLYLLP LCWVLTLLNS TLFLGNVEFF RVVSEYRASL QQRMNPKQEE 240
HAFESPPPPD VGGKDGLMDS TPALTPTESL SSQDLTPGSV EEAEEAEPDE EFKDAIEETH 300
LVVLEDDEGA PCPAEDELAL QDNGFLSKNE VLRSKVSRLT ERLRKRYPTN NFGNCTGCSA 360
TFSVLKKRRS CSNCGNSFCS RCCSFKVPKS SMGATAPEAQ RETVFVCASC NQTLSK 416 
Gene Ontology
 GO:0030424; C:axon; ISS:UniProtKB.
 GO:0030425; C:dendrite; ISS:UniProtKB.
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0032584; C:growth cone membrane; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0031175; P:neuron projection development; IDA:UniProtKB.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; ISS:UniProtKB.
 GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB. 
Interpro
 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF01363; FYVE 
SMART
 SM00064; FYVE 
PROSITE
 PS50178; ZF_FYVE 
PRINTS