UniProt Accession

 PUR3_ECOLI; P08179 

Genbank Protein ID

 M13747; U00096; AP009048; AF293167 

Genbank Nucleotide ID

 AAA83899.1; AAC75553.1; BAA16388.1; AAG14584.1 

Protein Name

 Phosphoribosylglycinamide formyltransferase 

Protein Synonyms/Alias

 5'-phosphoribosylglycinamide transformylase; GAR transformylase; GART 

Gene Name

 purN 

Gene Synonyms/Alias

 b2500; JW2485 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
37	VRAVFSNKADAFGLE	acetylation	[1]
114	IHPSLLPKYPGLHTH	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

  

Sequence Annotation

 REGION 11 13 5'-phosphoribosylglycinamide binding.
 REGION 89 92 10-formyltetrahydrofolate binding.
 REGION 140 144 10-formyltetrahydrofolate binding.
 REGION 170 173 5'-phosphoribosylglycinamide binding.
 ACT_SITE 108 108 Proton donor.
 BINDING 64 64 10-formyltetrahydrofolate.
 BINDING 106 106 10-formyltetrahydrofolate.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Purine biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 212 AA 

Protein Sequence

Gene Ontology

 GO:0008168; F:methyltransferase activity; IEA:InterPro.
 GO:0004644; F:phosphoribosylglycinamide formyltransferase activity; IDA:EcoCyc.
 GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0032259; P:methylation; IEA:GOC.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki. 

Interpro

 IPR002376; Formyl_transf_N.
 IPR001555; GART_AS.
 IPR004607; PurN_trans. 

Pfam

 PF00551; Formyl_trans_N 

SMART

  

PROSITE

 PS00373; GART 

PRINTS